Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

The continued integrity of biological systems depends on a balance between
interdependent elements at the molecular, cellular, and organismal levels. This is …

The fetal-to-adult switch in hematopoietic stem cell (HSC) behavior is characterized by
alterations in lineage output and entry into deep quiescence. Here we identify the …

Lin28 RNA-binding proteins are stem-cell factors that play key roles in development. Lin28
suppresses the biogenesis of let-7 microRNAs and regulates mRNA translation. Notably, let …

The human neocortex is undoubtedly considered a supreme accomplishment in mammalian
evolution. It features a prenatally established six-layered structure which remains plastic to …

Increased protein synthesis supports the rapid cell proliferation associated with cancer. The
Rpl24 Bst mutant mouse reduces the expression of the ribosomal protein RPL24 and has …

Like all other parts of the central nervous system, the mammalian neocortex undergoes
temporally ordered set of developmental events, including proliferation, differentiation …

Parkinson's disease (PD) is neurodegenerative movement disorder characterized by
degeneration of midbrain‐type dopamine (mDA) neurons in the substantia nigra (SN). The …

Diverse cell types in the central nervous system (CNS) are generated by a relatively small
pool of neural stem cells during early development. Spatial and temporal regulation of stem …

Animal or human models recapitulating brain ribosomopathies are incomplete, hampering
development of urgently needed therapies. Here, we generated genetic mouse and human …