Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

Small molecules that directly target MYC and are also well tolerated in vivo will provide
invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

The MYC oncoprotein is an essential transcription factor that regulates the expression of
many genes involved in cell growth, proliferation, and metabolic pathways. Thus, it is …

Transforming members of the MYC family (MYC, MYCL1, and MYCN) encode transcription
factors containing six highly conserved regions, termed MYC homology boxes (MBs). By …

While survival has improved for Burkitt lymphoma patients, potential differences in outcome
between pediatric and adult patients remain unclear. In both age groups, survival remains …

The c-Myc proto-oncogene encodes a transcription factor that is essential for cell growth and
proliferation and is broadly implicated in tumorigenesis. However, the biological functions …

High-intensity transcription and replication supercoil DNA to levels that can impede or halt
these processes. As a potent transcription amplifier and replication accelerator, the proto …

Silent information regulator 1 (SIRT1) represents an NAD+-dependent deacetylase that
inhibits proapoptotic factors including p53. Here we determined whether SIRT1 is …