Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies

OD Rangel-Huerta, B Pastor-Villaescusa, A Gil - Metabolomics, 2019 - Springer
Introduction Obesity is a disorder characterized by a disproportionate increase in body
weight in relation to height, mainly due to the accumulation of fat, and is considered a …

[HTML][HTML] A metabolomic approach to understanding the metabolic link between obesity and diabetes

S Park, KC Sadanala, EK Kim - Molecules and cells, 2015 - Elsevier
Obesity and diabetes arise from an intricate interplay between both genetic and
environmental factors. It is well recognized that obesity plays an important role in the …

Improved glucose homeostasis in obese mice treated with resveratrol is associated with alterations in the gut microbiome

MM Sung, TT Kim, E Denou, CLM Soltys, SM Hamza… - Diabetes, 2017 - Am Diabetes Assoc
Oral administration of resveratrol is able to improve glucose homeostasis in obese
individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted …

[HTML][HTML] Maternal obesity and the human milk metabolome: associations with infant body composition and postnatal weight gain

E Isganaitis, S Venditti, TJ Matthews, C Lerin… - The American journal of …, 2019 - Elsevier
Background Maternal obesity is a risk factor for childhood obesity; this is a major public
health concern given that∼ 40% of pregnant women are either overweight or obese …

Metabolomic analysis of obesity, metabolic syndrome, and type 2 diabetes: amino acid and acylcarnitine levels change along a spectrum of metabolic wellness

DM Libert, AS Nowacki, MR Natowicz - PeerJ, 2018 - peerj.com
Background Metabolic syndrome (MS) is a construct used to separate “healthy” from
“unhealthy” obese patients, and is a major risk factor for type 2 diabetes (T2D) and …

Biomarkers of morbid obesity and prediabetes by metabolomic profiling of human discordant phenotypes

S Tulipani, M Palau-Rodriguez, AM Alonso… - Clinica Chimica …, 2016 - Elsevier
Metabolomic studies aimed to dissect the connection between the development of type 2
diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult …

Altered metabolome of lipids and amino acids species: a source of early signature biomarkers of T2DM

A Hameed, P Mojsak, A Buczynska… - Journal of clinical …, 2020 - mdpi.com
Diabetes mellitus, a disease of modern civilization, is considered the major mainstay of
mortalities around the globe. A great number of biochemical changes have been proposed …

Diabetic macroangiopathy: Pathogenetic insights and novel therapeutic approaches with focus on high glucose-mediated vascular damage

R Madonna, D Pieragostino, CR Balistreri, C Rossi… - Vascular …, 2018 - Elsevier
Diabetic macroangiopathy–a specific form of accelerated atherosclerosis–is characterized
by intra-plaque new vessel formation due to excessive/abnormal neovasculogenesis and …

Tyrosine is associated with insulin resistance in longitudinal metabolomic profiling of obese children

C Hellmuth, FF Kirchberg, N Lass… - Journal of diabetes …, 2016 - Wiley Online Library
In obese children, hyperinsulinaemia induces adverse metabolic consequences related to
the risk of cardiovascular and other disorders. Branched‐chain amino acids (BCAA) and …

Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action

E Abbasi Oshaghi, MT Goodarzi… - Critical reviews in …, 2017 - Taylor & Francis
Abstract Resveratrol (RES), a well-known antioxidant, is present in numerous plant species
and, as a result, is easily obtained through dietary intake of plant-based foods and …