The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes

AJ Terkelsen, P Karlsson, G Lauria, R Freeman… - The lancet …, 2017 - thelancet.com
Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated
Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre …

Emerging biomarkers, tools, and treatments for diabetic polyneuropathy

GJ Bönhof, C Herder, A Strom, N Papanas… - Endocrine …, 2019 - academic.oup.com
Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …

[HTML][HTML] Diagnosing diabetic neuropathy: something old, something new

IN Petropoulos, G Ponirakis, A Khan… - … & metabolism journal, 2018 - ncbi.nlm.nih.gov
There are potentially many ways of assessing diabetic peripheral neuropathy (DPN).
However, they do not fulfill US Food and Drug Administration (FDA) requirements in relation …

Early nerve fibre regeneration in individuals with type 1 diabetes after simultaneous pancreas and kidney transplantation

S Azmi, M Jeziorska, M Ferdousi, IN Petropoulos… - Diabetologia, 2019 - Springer
Aims/hypothesis The study aimed to assess the impact on neuropathy of simultaneous
pancreas and kidney transplantation (SPK) in individuals with type 1 diabetes. Methods This …

Diabetic corneal neuropathy

H Mansoor, HC Tan, MTY Lin, JS Mehta… - Journal of clinical …, 2020 - mdpi.com
Diabetic keratopathy (DK) is a common, but underdiagnosed, ocular complication of
diabetes mellitus (DM) that has a significant economic burden. It is characterised by …

Scientific advances in and clinical approaches to small-fiber polyneuropathy: a review

AL Oaklander, M Nolano - JAMA neurology, 2019 - jamanetwork.com
Importance Small-fiber polyneuropathy involves preferential damage to the thinly myelinated
A-delta fibers, unmyelinated C sensory fibers, or autonomic or trophic fibers. Although this …

Corneal confocal microscopy predicts 4-year incident peripheral neuropathy in type 1 diabetes

N Pritchard, K Edwards, AW Russell, BA Perkins… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE This study determined if deficits in corneal nerve fiber length (CNFL) assessed
using corneal confocal microscopy (CCM) can predict future onset of diabetic peripheral …

An automatic tool for quantification of nerve fibers in corneal confocal microscopy images

X Chen, J Graham, MA Dabbah… - IEEE Transactions …, 2016 - ieeexplore.ieee.org
We describe and evaluate an automated software tool for nerve-fiber detection and
quantification in corneal confocal microscopy (CCM) images, combining sensitive nerve …

[HTML][HTML] Small fiber neuropathy in Parkinson's disease: a clinical, pathological and corneal confocal microscopy study

L Kass-Iliyya, S Javed, D Gosal, C Kobylecki… - Parkinsonism & related …, 2015 - Elsevier
Autonomic and somatic denervation is well established in Parkinson's disease (PD).
Objectives (1) To determine whether corneal confocal microscopy (CCM) can non-invasively …

Corneal confocal microscopy identifies small-fiber neuropathy in subjects with impaired glucose tolerance who develop type 2 diabetes

S Azmi, M Ferdousi, IN Petropoulos, G Ponirakis… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE Impaired glucose tolerance (IGT) through to type 2 diabetes is thought to confer
a continuum of risk for neuropathy. Identification of subjects at high risk of developing type 2 …