Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are expressed in a
variety of tumors. Activation of the PDGF/PDGFR signaling pathway is associated with …

Simple Summary Chondrosarcomas develop chemoresistance to standard anticancer
drugs, making it difficult to control unresectable or metastatic chondrosarcomas. To improve …

Doxorubicin is a commonly used anticancer agent that can cause debilitating and
irreversible cardiac injury. The initiating mechanisms contributing to this side effect remain …

The frequent occurrence of multidrug resistance (MDR) conferred by the overexpression of
ATP-binding cassette (ABC) transporters ABCB1 and ABCG2 in cancer cells remains a …

Several ABC transporters (eg, ABCB1, ABCB4, ABCC1–5, ABCC10, ABCG2 and ABCG4)
are known to contribute to the phenomenon of cancer-related multidrug resistance (MDR)[1] …

The development of multidrug resistance (MDR) in cancer patients driven by the
overexpression of ATP-binding cassette (ABC) transporter ABCB1 or ABCG2 in cancer cells …

The overexpression of the human ATP-binding cassette (ABC) drug transporter ABCB1 (P-
glycoprotein, P-gp) or ABCG2 (breast cancer resistance protein, BCRP) in cancer cells often …

The development of multidrug resistance (MDR) in cancer patients, which is often
associated with the overexpression of ABCB1 (MDR1, P-glycoprotein) in cancer cells …

Standard chemotherapy for soft tissue sarcomas has shown limited efficacy. Here, we
sought to evaluate whether β-adrenergic receptor (β-AR) signalling contributed to the …

ATP-binding cassette transporters, including ABCB1 (P-glycoprotein) and ABCG2
(BCRP/MXR/ABCP), are pivotal in multidrug resistance (MDR) development in cancer …