Reactive organometallic intermediates present a distinct opportunity for the creation of novel
carbon-carbon and carbon-heteroatom bonds. Whereas their utility in synthesis is well …

During the first year of the outbreak of the COVID-19 pandemic, many drugs and drug
candidates have been evaluated as treatment options. None yet has proved to be an …

As remdesivir is the first approved treatment for COVID-19 (SARS-CoV-2), its production is
likely to be of vital importance in the near future. Continuous flow processing has been …

In a rapidly changing environment, such as the current COVID-19 pandemic, continuous
flow reactors bear the potential to increase the production of urgently needed active …

A novel, efficient, and atom-economical approach for the construction of quinazolinones
from 2-nitrobenzaldehydes has been unveiled via copper-catalyzed nitrile formation …

We report an alternative approach to the unnatural nucleobase fragment seen in remdesivir
(Veklury). Remdesivir displays broad-spectrum antiviral activity and is currently being …

The broad-spectrum antiviral Remdesivir, a monophosphate nucleoside analogue prodrug
(ProTide), was repurposed. In May 2020, it received emergency approval by the FDA, being …

Epimerization and recycling of an unwanted piperazine stereoisomer enabled a more
sustainable, concise, and high-yielding synthesis of a chiral adagrasib building block. The …

Access to carbocyclic C-nucleosides (CC-Ns) is currently restricted. The few methods
available to make CC-Ns suffer from long syntheses and poor modularity, hindering the …

Biocatalysis has undergone a remarkable transition in the last two decades, from being
considered a niche technology to playing a much more relevant role in organic synthesis …