The rational design of theoretical minimal RNA rings predetermines AUG as the universal start codon. This design maximizes coded amino acid diversity over minimal sequence …
Small circular RNAs occur in many cells. Theoretical considerations designed to mimick primordial RNAs designed 25 theoretical, minimal 22-nucleotide long circular RNAs (RNA …
H Seligmann, G Warthi - Computational and Structural Biotechnology …, 2017 - Elsevier
A new codon property, codon directional asymmetry in nucleotide content (CDA), reveals a biologically meaningful genetic code dimension: palindromic codons (first and last …
J Demongeot, H Seligmann - Acta Biotheoretica, 2019 - Springer
Theoretical minimal RNA rings attempt to mimick life's primitive RNAs. At most 25 22- nucleotide-long RNA rings code once for each biotic amino acid, a start and a stop codon …
CJ Michel, H Seligmann - Biosystems, 2014 - Elsevier
The C 3 self-complementary circular code X identified in genes of prokaryotes and eukaryotes is a set of 20 trinucleotides enabling reading frame retrieval and maintenance, ie …
H Seligmann, D Raoult - Frontiers in Microbiology, 2018 - frontiersin.org
We examine the hypothesis that de novo template-free RNAs still form spontaneously, as they did at the origins of life, invade modern genomes, contribute new genetic material …
J Demongeot, H Seligmann - Journal of Molecular Evolution, 2020 - Springer
Theoretical minimal RNA ring design ensures coding over the shortest length once for each coding signal (start and stop codons, and each amino acid) and their hairpin configuration …
H Seligmann - Computational and Structural Biotechnology Journal, 2018 - Elsevier
Several hypotheses predict ranks of amino acid assignments to genetic code's codons. Analyses here show that average positions of amino acid species in proteins correspond to …
H Seligmann - Computational Biology and Chemistry, 2012 - Elsevier
Mitochondrial genes code for additional proteins after+ 2 frameshifts by reassigning stops to code for amino acids, which defines overlapping genetic codes for overlapping genes …