Role of telomeres and telomerase in aging and cancer
JW Shay - Cancer discovery, 2016 - AACR
Telomeres progressively shorten throughout life. A hallmark of advanced malignancies is
the ability for continuous cell divisions that almost universally correlates with the stabilization …
the ability for continuous cell divisions that almost universally correlates with the stabilization …
Evolutionary determinants of cancer
M Greaves - Cancer discovery, 2015 - AACR
Our understanding of cancer is being transformed by exploring clonal diversity, drug
resistance, and causation within an evolutionary framework. The therapeutic resilience of …
resistance, and causation within an evolutionary framework. The therapeutic resilience of …
A multidimensional systems biology analysis of cellular senescence in aging and disease
Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …
SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species
DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is
based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel …
based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel …
Comparative oncology: what dogs and other species can teach us about humans with cancer
JD Schiffman, M Breen - Philosophical Transactions of …, 2015 - royalsocietypublishing.org
Over 1.66 million humans (approx. 500/100 000 population rate) and over 4.2 million dogs
(approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The …
(approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The …
The genetics of aging: a vertebrate perspective
Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …
were discovered in invertebrates. However, the genetics of aging is more complex in …
The relationship between telomere length and mortality risk in non-model vertebrate systems: a meta-analysis
Telomere length (TL) has become a biomarker of increasing interest within ecology and
evolutionary biology, and has been found to predict subsequent survival in some recent …
evolutionary biology, and has been found to predict subsequent survival in some recent …
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation
Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences
P Monaghan, SE Ozanne - Philosophical Transactions of …, 2018 - royalsocietypublishing.org
Much telomere loss takes place during the period of most rapid growth when cell
proliferation and potentially energy expenditure are high. Fast growth is linked to reduced …
proliferation and potentially energy expenditure are high. Fast growth is linked to reduced …
Sirtuin 6: linking longevity with genome and epigenome stability
Sirtuin 6 (SIRT6) has been in the spotlight of aging research because progeroid phenotypes
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …