Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Inflammatory bowel diseases (IBDs) are chronic problems of gastrointestinal tract (GIT) with
poorly understood aetiology. Patients with any of the two common entities, Crohn's disease …

USP22, the deubiquitinating subunit of the SAGA transcriptional cofactor complex, is a
member of an 11-gene “death-from-cancer” signature. USP22 has been considered an …

Abstract RNF40 (OMIM: 607700) is a really interesting new gene (RING) finger E3 ubiquitin
ligase containing multiple coiled-coil domains and a C-terminal RING finger motif, which …

Simple Summary Post-translational modifications (PTM) of histone tails represent
epigenomic regulation of the chromatin landscape, influencing gene expression and the …

The Toll signaling pathway was initially identified for its involvement in the control of early
embryogenesis. It was later shown to be also part of a major innate immune pathway …

Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due
to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC …

Arsenic is a worldwide environmental pollutant that can impair human health. Previous
studies have identified mental disorders induced by arsenic, but the environmental exposure …

There is growing evidence highlighting the importance of monoubiquitination as part of the
histone code. Monoubiquitination, the covalent attachment of a single ubiquitin molecule at …

As a member of the 11-gene “death-from-cancer” gene expression signature,
overexpression of the Ubiquitin-Specific Protease 22 (USP22) was associated with poor …