[HTML][HTML] Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum
J Oberstaller, L Zoungrana, CD Bannerman… - International Journal for …, 2021 - Elsevier
Resistance to antimalarial drugs, and in particular to the artemisinin derivatives and their
partner drugs, threatens recent progress toward regional malaria elimination and eventual …
partner drugs, threatens recent progress toward regional malaria elimination and eventual …
Heat Shock Protein 90 Regulates the Activity of Histone Deacetylase Sir2 in Plasmodium falciparum
W Tabassum, M Bhattacharya, S Bakshi… - Msphere, 2022 - Am Soc Microbiol
Sir2 protein of Plasmodium falciparum has been implicated to play crucial roles in the
silencing of subtelomeric var genes and rRNA. It is also involved in telomere length …
silencing of subtelomeric var genes and rRNA. It is also involved in telomere length …
Bloom helicase along with recombinase Rad51 repairs the mitochondrial genome of the malaria parasite
P Jha, A Gahlawat, S Bhattacharyya, S Dey, KA Kumar… - Msphere, 2021 - Am Soc Microbiol
The homologous recombination (HR) pathway has been implicated as the predominant
mechanism for the repair of chromosomal DNA double-strand breaks (DSBs) of the malarial …
mechanism for the repair of chromosomal DNA double-strand breaks (DSBs) of the malarial …
[HTML][HTML] Structural exploration of the PfBLM Helicase-ATP Binding Domain and implications in the quest for antimalarial therapies
Methods: To tackle this issue, it is imperative to identify new effective drug candidates
against the malaria parasite that exhibit minimal toxicity. This study focuses on discovering …
against the malaria parasite that exhibit minimal toxicity. This study focuses on discovering …
Synergistic action between PfHsp90 inhibitor and PfRad51 inhibitor induces elevated DNA damage sensitivity in the malaria parasite
W Tabassum, P Singh, N Suthram… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
The DNA recombinase Rad51 from the human malaria parasite Plasmodium falciparum has
emerged as a potential drug target due to its central role in the homologous recombination …
emerged as a potential drug target due to its central role in the homologous recombination …
Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation
The human malaria parasite undergoes a noncanonical cell division, namely,
endoreduplication, where several rounds of nuclear, mitochondrial, and apicoplast …
endoreduplication, where several rounds of nuclear, mitochondrial, and apicoplast …