Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion
Tryptophan catabolism in cancer is increasingly being recognized as an important
microenvironmental factor that suppresses antitumor immune responses. It has been …
microenvironmental factor that suppresses antitumor immune responses. It has been …
[HTML][HTML] Linking the human gut microbiome to inflammatory cytokine production capacity
Gut microbial dysbioses are linked to aberrant immune responses, which are often
accompanied by abnormal production of inflammatory cytokines. As part of the Human …
accompanied by abnormal production of inflammatory cytokines. As part of the Human …
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Activation of the aryl hydrocarbon receptor (AHR) by environmental xenobiotic toxic
chemicals, for instance 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in …
chemicals, for instance 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in …
NAD+ metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity
T Meyer, D Shimon, S Youssef… - Proceedings of the …, 2022 - National Acad Sciences
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS). Astrocytes are the most abundant glial cells in the CNS, and their dysfunction …
(CNS). Astrocytes are the most abundant glial cells in the CNS, and their dysfunction …
Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2, 3 …
Mesenchymal stem cells (MSC) display unique suppressive properties on T-cell immunity,
thus representing an attractive vehicle for the treatment of conditions associated with harmful …
thus representing an attractive vehicle for the treatment of conditions associated with harmful …
Cancer cell metabolic reprogramming: a keystone for the response to immunotherapy
M Cerezo, S Rocchi - Cell Death & Disease, 2020 - nature.com
By targeting the tumor microenvironment to stimulate antitumor immunity, immunotherapies
have revolutionized cancer treatment. However, many patients do not respond initially or …
have revolutionized cancer treatment. However, many patients do not respond initially or …
The roles of aryl hydrocarbon receptor in immune responses
A number of recent studies have examined the functions of aryl hydrocarbon receptor (Ahr)
in the immune system. Also known as dioxin receptor, Ahr is a ligand-activated transcription …
in the immune system. Also known as dioxin receptor, Ahr is a ligand-activated transcription …
[HTML][HTML] Regulation of ferroptosis by amino acid metabolism in cancer
J Yang, X Dai, H Xu, Q Tang, F Bi - International Journal of …, 2022 - ncbi.nlm.nih.gov
Ferroptosis, a new form of programmed necrosis characterized by iron-dependent lethal
accumulation of lipid hydroperoxides, is associated with many human diseases. Targeting …
accumulation of lipid hydroperoxides, is associated with many human diseases. Targeting …
The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress
Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for
NAD+, an important enzymatic cofactor for enzymes such as the DNA repair protein PARP …
NAD+, an important enzymatic cofactor for enzymes such as the DNA repair protein PARP …