Bond-selective imaging by optically sensing the mid-infrared photothermal effect

Y Bai, J Yin, JX Cheng - Science advances, 2021 - science.org
Mid-infrared (IR) spectroscopic imaging using inherent vibrational contrast has been broadly
used as a powerful analytical tool for sample identification and characterization. However …

Mid-infrared photothermal microscopy: principle, instrumentation, and applications

Q Xia, J Yin, Z Guo, JX Cheng - The Journal of Physical Chemistry …, 2022 - ACS Publications
Midinfrared photothermal (MIP) microscopy, also called optical photothermal infrared (O-
PTIR) microscopy, is an emerging tool for bond-selective chemical imaging of living …

Label-free mid-infrared photothermal live-cell imaging beyond video rate

G Ishigane, K Toda, M Tamamitsu, H Shimada… - Light: Science & …, 2023 - nature.com
Advancement in mid-infrared (MIR) technology has led to promising biomedical applications
of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR …

Bond-selective fluorescence imaging with single-molecule sensitivity

H Wang, D Lee, Y Cao, X Bi, J Du, K Miao, L Wei - Nature photonics, 2023 - nature.com
Bioimaging harnessing optical contrasts and chemical specificity is of vital importance in
probing complex biology. Vibrational spectroscopy based on mid-infrared excitation can …

Infrared spectroscopic laser scanning confocal microscopy for whole-slide chemical imaging

K Yeh, I Sharma, K Falahkheirkhah, MP Confer… - Nature …, 2023 - nature.com
Chemical imaging, especially mid-infrared spectroscopic microscopy, enables label-free
biomedical analyses while achieving expansive molecular sensitivity. However, its slow …

Video-rate mid-infrared photothermal imaging by single-pulse photothermal detection per pixel

J Yin, M Zhang, Y Tan, Z Guo, H He, L Lan… - Science …, 2023 - science.org
By optically sensing absorption-induced photothermal effect, mid-infrared (IR) photothermal
(MIP) microscope enables super-resolution IR imaging of biological systems in water …

Digital histopathology by infrared spectroscopic imaging

R Bhargava - Annual Review of Analytical Chemistry, 2023 - annualreviews.org
Infrared (IR) spectroscopic imaging records spatially resolved molecular vibrational spectra,
enabling a comprehensive measurement of the chemical makeup and heterogeneity of …

Fluorescence-detected mid-infrared photothermal microscopy

Y Zhang, H Zong, C Zong, Y Tan, M Zhang… - Journal of the …, 2021 - ACS Publications
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a
visible beam senses the photothermal effect induced by a pulsed infrared laser. This …

Hyperspectral infrared microscopy with visible light

AV Paterova, SM Maniam, H Yang, G Grenci… - Science …, 2020 - science.org
Hyperspectral microscopy is an imaging technique that provides spectroscopic information
with high spatial resolution. When applied in the relevant wavelength region, such as in the …

Vibrational spectroscopic detection of a single virus by mid-infrared photothermal microscopy

Y Zhang, C Yurdakul, AJ Devaux, L Wang… - Analytical …, 2021 - ACS Publications
We report a confocal interferometric mid-infrared photothermal (MIP) microscope for ultra-
sensitive and spatially resolved chemical imaging of individual viruses. The interferometric …