Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …

It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …

The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in
tissues, is key for a broad range of immunological research, including vaccine responses …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

During persistent viral infections, chronic immune activation, negative immune regulator
expression, an elevated interferon signature, and lymphoid tissue destruction correlate with …

T cell exhaustion is common during chronic infections. Although CD4+ T cells are critical for
controlling viral load during chronic viral infections, less is known about their differentiation …

Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is
associated with hyperimmune activation and disease progression in persistent infections …

Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …

The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long
been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who …