The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and
deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an …

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities
for therapeutic intervention. The acidic microenvironment within a tumour can promote …

We have recently demonstrated that reactive glial cells can be directly reprogrammed into
functional neurons by a single neural transcription factor, NeuroD1. Here we report that a …

Under ischemic and inflammatory circumstances, such as allergic airway asthma,
rheumatoid arthritis, atherosclerosis, and tumors, extracellular acidification occurs due to the …

Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for
metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis …

GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-
protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a …

Recent studies have demonstrated that human astrocytes and fibroblasts can be directly
converted into functional neurons by small molecules. However, fibroblasts, as a potentially …

The maintenance of the resident adult neural stem/progenitor cell (NSPC) pool depends on
the precise balance of proliferation, differentiation, and maintenance of the undifferentiated …

Glioblastoma multiforme, a type of deadly brain cancer, originates most commonly from
astrocytes found in the brain. Current multimodal treatments for glioblastoma minimally …

Adult neurogenesis occurs throughout life in the mammalian hippocampus and is essential
for memory and mood control. There is significant interest in identifying ways to promote …