Importance The initial clinical sign of pubertal onset in girls is breast gland development
(thelarche). Although numerous studies have used recalled age at menarche (first …

BACKGROUND: This article is a comprehensive overview of dysmenorrhea and a
systematic review of the available literature on the use of nonsteroidal anti-inflammatory …

OBJECTIVE. Recent publications showing unexpectedly early breast development in
American girls created debate worldwide. However, secular trend analyses are often limited …

Two recent epidemiological studies (PROS and NHANES III) from the USA noted earlier
sexual maturation in girls, leading to increased attention internationally to the age at onset of …

Background Age at menarche is considered a reliable prognostic factor for idiopathic
scoliosis and varies in different geographic latitudes. Adolescent idiopathic scoliosis …

Objective: A decrease in age at pubertal onset has been observed internationally. The aim
of this study was to describe a large cohort of Caucasian girls referred with signs of early …

PURPOSE: To update the information on age at menarche in the Italian population and to
verify the influence of genetic, nutritional, and socioeconomic factors on menarcheal age …

This study describes the timing of puberty in 8‐to 13‐year‐old girls enrolled in the Avon
Longitudinal Study of Parents and Children (ALSPAC) and identifies factors associated with …

Background Some pediatric endocrinologists recommend that girls with central precocious
puberty (CPP) have cranial magnetic resonance imaging (MRI) performed only if they are …

Objective: The study aimed to determine the cognitive effect of the Val 108/158 Met
polymorphism in the catechol-O-methyltransferase (COMT) gene in children before and …