Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease

SP Yu, MQ Jiang, SS Shim, S Pourkhodadad… - Molecular …, 2023 - Springer
Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

[HTML][HTML] Na+-K+–ATPase-mediated signal transduction: from protein interaction to cellular function

Z Xie, T Cai - Molecular interventions, 2003 - triggered.stanford.clockss.org
Abstract The Na+-K+-ATPase, or Na+ pump, is a member of the P-type ATPase superfamily.
In addition to pumping ions, Na+-K+-ATPase is engaged in assembly of multiple protein …

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

X Chen, W Li, J Ren, D Huang, W He, Y Song, C Yang… - Cell research, 2014 - nature.com
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of
receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also …

Chronic cigarette smoking: implications for neurocognition and brain neurobiology

TC Durazzo, DJ Meyerhoff, SJ Nixon - International journal of …, 2010 - mdpi.com
Compared to the substantial volume of research on the general health consequences
associated with chronic smoking, little research has been specifically devoted to the …

Regulation and critical role of potassium homeostasis in apoptosis

SP Yu - Progress in neurobiology, 2003 - Elsevier
Programmed cell death or apoptosis is broadly responsible for the normal homeostatic
removal of cells and has been increasingly implicated in mediating pathological cell loss in …

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

L Wei, ZZ Wei, MQ Jiang, O Mohamad, SP Yu - Progress in neurobiology, 2017 - Elsevier
One of the exciting advances in modern medicine and life science is cell-based
neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The …

Ion channels in cancer: future perspectives and clinical potential

F Lang, C Stournaras - … of the Royal Society B: Biological …, 2014 - royalsocietypublishing.org
Ion transport across the cell membrane mediated by channels and carriers participate in the
regulation of tumour cell survival, death and motility. Moreover, the altered regulation of …

Activation of K+ channels: an essential pathway in programmed cell death

CV Remillard, JXJ Yuan - American Journal of Physiology …, 2004 - journals.physiology.org
Cell apoptosis and proliferation are two counterparts in sharing the responsibility for
maintaining normal tissue homeostasis. In recent years, the process of the programmed cell …

Cell shrinkage and monovalent cation fluxes: role in apoptosis

CD Bortner, JA Cidlowski - Archives of biochemistry and biophysics, 2007 - Elsevier
The loss of cell volume or cell shrinkage has been a morphological hallmark of the
programmed cell death process known as apoptosis. This isotonic loss of cell volume has …

[HTML][HTML] Neurotoxicity of nanoscale materials

A Karmakar, Q Zhang, Y Zhang - Journal of Food and Drug Analysis, 2014 - Elsevier
Nanotechnology has been applied in consumer products and commercial applications,
showing a significant impact on almost all industries and all areas of society. Significant …