Sepsis-associated encephalopathy (SAE) is a critical neurological complication of sepsis
and represents a crucial factor contributing to high mortality and adverse prognosis in septic …

Memories are dynamic constructs whose properties change with time and experience. The
biological mechanisms underpinning these dynamics remain elusive, particularly …

Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity
within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) …

The immediate early gene FOS is frequently used as a marker for highly active neurons.
Implicit in this use is the assumption that there is a correlation between neuronal spiking and …

Memory traces for behavioral experiences, such as fear conditioning or taste aversion, are
believed to be stored through biophysical and molecular changes in distributed neuronal …

Retinoic acid (RA), derived from vitamin A (retinol), plays a crucial role in modulating
neuroplasticity within the adult brain. Perturbations in RA signaling have been associated …

Desmoplakin (Dsp) is a component of desmosomal cell–cell junctions that interacts with the
cadherin complex and cytoskeletal intermediate filaments. In addition to its function as an …

Pattern separation is a valuable computational function performed by neuronal circuits, such
as the dentate gyrus, where dissimilarity between inputs is increased, reducing noise and …

The voltage-gated calcium channel subunit α2δ-2 controls calcium-dependent signaling in
neurons, and loss of this subunit causes epilepsy in both mice and humans. To determine …

Expression of the immediate early gene cFos modifies the epigenetic landscape of activated
neurons with downstream effects on synaptic plasticity. The production of cFos is inhibited …