Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Nowadays, epigenetics is of great research value as a new gateway that can solve the
sophisticated mysteries behind neurodegenerative diseases. Epigenetic mechanisms …

Susceptibility to psychiatric disorders seems to be influenced by environmental disturbances
throughout all stages of life. Epigenetics is described as a key “bridge” between gene and …

Epilepsy is a network disorder driven by fundamental changes in the function of the cells
which compose these networks. Driving this aberrant cellular function are large scale …

Ogt-mediated O-GlcNAcylation is enriched in the nervous system and involves in neuronal
development, brain function and neurological diseases. However, the roles of Ogt and O …

In bone biology, epigenetics plays a key role in mesenchymal stem cells'(MSCs)
commitment towards osteoblasts. It involves gene regulatory mechanisms governed by …

Patients with irritable bowel syndrome (IBS) experience not only enhanced visceral pain but
also emotional comorbidities, such as anxiety and depression. Early life stress (ELS) is a …

Histone methylation is essential for regulating gene expression during organogenesis to
maintain stem cells and execute a proper differentiation program for their descendants. Here …

Neurogenesis is the process through which neural stem and progenitor cells generate
neurons. During the development of the mouse neocortex, stem and progenitor cells …

The transition from multipotent neural stem cells (NSCs) to terminally differentiated neurons
is a multistep process, and the transition is finely regulated by transcription factors with basic …