Oxidative stress (OS) arises when the body is subjected to harmful endogenous or
exogenous factors that overwhelm the antioxidant system. There is increasing evidence that …

Simple Summary Cancers in the head and neck region are often aggressive and poorly
respond to both irradiation or chemotherapy. Chemotherapy is currently limited by a small …

Optimal treatment of cancer requires diagnostic methods to facilitate therapy choice and
prevent ineffective treatments. Direct assessment of therapy response in viable tumor …

Precision treatment of cancer requires knowledge on active tumor driving signal
transduction pathways to select the optimal effective targeted treatment. Currently only a …

Simple Summary Androgen receptor signaling seems pivotal in aggressive salivary duct
carcinoma. However, androgen deprivation therapy (ADT) frequently fails, emphasizing the …

For many diseases, including cancer, infections, and auto-immune diseases, the immune
response is a major determinant of disease progression, response to therapy, and clinical …

The Notch pathway is a key cancer driver and is important in tumor progression. Early
research suggested that Notch activity was highly dependent on the expression of the …

Simple Summary Immunotherapy enhances the immune response against cancer and is
potentially curative. Unfortunately, few patients with breast cancer benefit from this therapy. It …

Abstract Background/Objectives: Advances in treatment options have barely improved the
prognosis of ovarian carcinoma (OC) in recent decades. The inherent heterogeneity of OC …

Abstract CD8+ exhausted T cells (CD8+ Tex) played a vital role in the progression and
therapeutic response of cancer. However, few studies have fully clarified the characters of …