Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium

JE Fish, PA Marsden - Cellular and Molecular Life Sciences CMLS, 2006 - Springer
The vascular endothelium plays a crucial role in regulating normal blood vessel physiology.
The gene products responsible are commonly expressed exclusively, or preferentially, in …

The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks

K Vázquez-Arreguín, D Tantin - Biochimica Et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
The metazoan-specific POU domain transcription factor family comprises activities
underpinning developmental processes such as embryonic pluripotency and neuronal …

Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study

SM Langevin, DC Koestler, BC Christensen… - Epigenetics, 2012 - Taylor & Francis
Head and neck cancer accounts for an estimated 47,560 new cases and 11,480 deaths
annually in the United States, the majority of which are squamous cell carcinomas (HNSCC) …

[HTML][HTML] Octamer-binding transcription factors: genomics and functions

FQ Zhao - Frontiers in bioscience (Landmark edition), 2013 - ncbi.nlm.nih.gov
Abstract The Octamer-binding proteins (Oct) are a group of highly conserved transcription
factors that specifically bind to the octamer motif (ATGCAAAT) and closely related …

Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice

VEH Wang, T Schmidt, J Chen, PA Sharp… - Molecular and Cellular …, 2004 - Taylor & Francis
Oct-1 is a sequence-specific DNA binding transcription factor that is believed to regulate a
large group of tissue-specific and ubiquitous genes. Both Oct-1 and the related but tissue …

Different N-terminal isoforms of Oct-1 control expression of distinct sets of genes and their high levels in Namalwa Burkitt's lymphoma cells affect a wide range of …

EV Pankratova, AG Stepchenko… - Nucleic Acids …, 2016 - academic.oup.com
Oct-1 transcription factor has various functions in gene regulation. Its expression level is
increased in several types of cancer and is associated with poor survival prognosis. Here we …

Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2

NN Luchina, IV Krivega, EV Pankratova - Immunology letters, 2003 - Elsevier
POU homeodomain proteins are important regulators of ubiquitous as well as tissue-specific
transcription. Ubiquitously expressed Oct-1 and tissue-specific Oct-2 proteins are members …

[HTML][HTML] The regulatory interplay between Oct-1 isoforms contributes to hematopoiesis and the isoforms imbalance correlates with a malignant transformation of B cells

EV Pankratova, AG Stepchenko, ID Krylova… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Abstract Oct-1 (POU2F1) is a DNA-binding transcription regulator and its level being highly
increased in many human cancers. Oct-1 is present in the human cells as a family of …

Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress

AG Stepchenko, TN Portseva, IA Glukhov… - Scientific Reports, 2021 - nature.com
The emergence of new primate-specific genes is an essential factor in human and primate
brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher …

Cloning, genomic organization, expression, and effect on β-casein promoter activity of a novel isoform of the mouse Oct-1 transcription factor

FQ Zhao, Y Zheng, B Dong, T Oka - Gene, 2004 - Elsevier
The ubiquitously expressed transcription factor Oct-1, a member of the POU domain factors,
is involved in the regulation of expression of many tissue-specific and house-keeping genes …