Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy

G Hajishengallis, T Chavakis… - Periodontology 2000, 2020 - Wiley Online Library
Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

[HTML][HTML] Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1

Y Gao, Y Chi, Y Chen, W Wang, H Li, W Zheng… - Nature …, 2023 - nature.com
Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been
extensively investigated for their therapeutic potential in treating inflammatory disorders …

Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells

A Qadir, S Liang, Z Wu, Z Chen, L Hu… - International journal of …, 2020 - mdpi.com
Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

[HTML][HTML] Advances in regenerative therapy: A review of the literature and future directions

EH Ntege, H Sunami, Y Shimizu - Regenerative therapy, 2020 - Elsevier
There is enormous global anticipation for stem cell-based therapies that are safe and
effective. Numerous pre-clinical studies present encouraging results on the therapeutic …

The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells

Q Li, Z Gao, Y Chen, MX Guan - Protein & cell, 2017 - Springer
Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged
as important tools for tissue engineering due to their differentiation potential along various …

Age-related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development

P Ganguly, JJ El-Jawhari, PV Giannoudis… - Cell …, 2017 - journals.sagepub.com
Aging at the cellular level is a complex process resulting from accumulation of various
damages leading to functional impairment and a reduced quality of life at the level of the …

Characterization of bone marrow-derived mesenchymal stem cells in aging

N Baker, LB Boyette, RS Tuan - Bone, 2015 - Elsevier
Adult mesenchymal stem cells are a resource for autologous and allogeneic cell therapies
for immune-modulation and regenerative medicine. However, patients most in need of such …

[HTML][HTML] Microenvironmental contributions to hematopoietic stem cell aging

YH Ho, S Méndez-Ferrer - Haematologica, 2020 - ncbi.nlm.nih.gov
Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …

[HTML][HTML] Usage of human mesenchymal stem cells in cell-based therapy: advantages and disadvantages

HJ Kim, JS Park - Development & reproduction, 2017 - ncbi.nlm.nih.gov
The use of human mesenchymal stem cells (hMSCs) in cell-based therapy has attracted
extensive interest in the field of regenerative medicine, and it shows applications to …