Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Oxazolidinones: mechanisms of resistance and mobile genetic elements involved

A Brenciani, G Morroni, S Schwarz… - Journal of …, 2022 - academic.oup.com
The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the
treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind …

Oxazolidinone antibiotics: chemical, biological and analytical aspects

C Foti, A Piperno, A Scala, O Giuffrè - Molecules, 2021 - mdpi.com
This review covers the main aspects concerning the chemistry, the biological activity and the
analytical determination of oxazolidinones, the only new class of synthetic antibiotics …

Cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems

B Gupta, V Mishra, S Gharat, M Momin, A Omri - Pharmaceuticals, 2021 - mdpi.com
One of the major impediments to drug development is low aqueous solubility and thus poor
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …

Design and synthesis of novel antimicrobial agents

Z Breijyeh, R Karaman - Antibiotics, 2023 - mdpi.com
The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection

Y Weng, H Chen, X Chen, H Yang, CH Chen… - Nature …, 2022 - nature.com
The prodrug approach has emerged as a promising solution to combat bacterial resistance
and enhance treatment efficacy against bacterial infections. Here, we report an adenosine …

Fluoroquinolones hybrid molecules as promising antibacterial agents in the fight against antibacterial resistance

IA Lungu, OL Moldovan, V Biriș, A Rusu - Pharmaceutics, 2022 - mdpi.com
The emergence of bacterial resistance has motivated researchers to discover new
antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential …

[HTML][HTML] The role of Cathepsin B in pathophysiologies of non-tumor and tumor tissues: a systematic review

J Wang, M Zheng, X Yang, X Zhou, S Zhang - Journal of Cancer, 2023 - ncbi.nlm.nih.gov
Cathepsin B (CTSB), a lysosomal cysteine protease, plays an important role in human
physiology and pathology. CTSB is associated with various human diseases, and its …

[HTML][HTML] Recent advances in prodrug-based nanoparticle therapeutics

KJ Chen, AJ Plaunt, FG Leifer, JY Kang… - European Journal of …, 2021 - Elsevier
Extensive research into prodrug modification of active pharmaceutical ingredients and
nanoparticle drug delivery systems has led to unprecedented levels of control over the …

[HTML][HTML] Anthelmintics for drug repurposing: Opportunities and challenges

SE Alavi, HE Shahmabadi - Saudi Pharmaceutical Journal, 2021 - Elsevier
Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …