Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

One of the central questions in neuroscience is how particular tasks, or computations, are
implemented by neural networks to generate behavior. The prevailing view has been that …

Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from
numerous subunit combinations that compose channel-receptor complexes with varied …

Tuft dendrites are the main target for feedback inputs innervating neocortical layer 5
pyramidal neurons, but their properties remain obscure. We report the existence of N-methyl …

Intracellular recordings in vivo have shown that neocortical neurons are subjected to an
intense synaptic bombardment in intact networks and are in a'high-conductance'state. In …

Dendrites are the main recipients of synaptic inputs and are important sites that determine
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …

The detection and discrimination of temporal sequences is fundamental to brain function
and underlies perception, cognition, and motor output. By applying patterned, two-photon …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

Cortical pyramidal neurons receive thousands of synaptic inputs arriving at different
dendritic locations with varying degrees of temporal synchrony. It is not known if different …