The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

Transforming growth factor-β (TGF-β) is a central regulator in chronic liver disease
contributing to all stages of disease progression from initial liver injury through inflammation …

Liver fibrosis occurs in response to any etiology of chronic liver injury including hepatitis B
and C, alcohol consumption, fatty liver disease, cholestasis, and autoimmune hepatitis …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Hepatic inflammation drives hepatic stellate cells (HSC), resulting in liver fibrosis. The
Farnesoid-X receptor (FXR) antagonizes inflammation through NF-κB inhibition. We …

Recent advances in our understanding of the molecular pathways that control the link of
inflammation with organ fibrosis and autoimmune diseases point to the epithelial to …

Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease and
a risk factor for cirrhosis and hepatocellular carcinoma. The pathological features of NASH …

This review describes precisely the consequence of TGFβ1 prevalence in the organism, and
its significant influence on physiological and pathophysiological processes. Organ and …

Connective tissue growth factor (CTGF= CCN2), one of six members of cysteine‐rich,
secreted, heparin‐binding proteins with a modular structure, is recognized as an important …

Hepatic fibrosis : Current Opinion in Gastroenterology Hepatic fibrosis : Current Opinion in
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