Instant Macrocyclizations via Multicomponent Reactions
M Fragkiadakis, PK Anastasiou… - The Journal of …, 2023 - ACS Publications
Macrocycles fascinate chemists due to both their structure and their applications. However,
we still lack efficient and sustainable synthetic methods, giving us straightforward access to …
we still lack efficient and sustainable synthetic methods, giving us straightforward access to …
Discovery and In Vivo Exploration of 1,3,4-Oxadiazole and α-Fluoroacrylate Containing IL-17 Inhibitors
J Velcicky, MR Bauer, A Schlapbach… - Journal of Medicinal …, 2024 - ACS Publications
IL-17, a pro-inflammatory cytokine produced mainly by Th17 cells, is involved in the immune
response to fungal and bacterial infections, whereas its aberrant production is associated …
response to fungal and bacterial infections, whereas its aberrant production is associated …
Ugi 5-center-4-component reaction of α-amino aldehydes and its application in synthesis of 2-oxopiperazines
M Splandesci, MZ Wróbel, ID Madura, M Dawidowski - Molecular Diversity, 2024 - Springer
A synthetic route leading to densely functionalized 2-oxopiperazines is presented. The
strategy employs a 5-center-4-component variant of Ugi multicomponent reaction followed …
strategy employs a 5-center-4-component variant of Ugi multicomponent reaction followed …
Thiazole‐based IL‐17 inhibitors discovered by scaffold morphing
J Velcicky, E Ngo, MR Bauer, A Meyer… - ChemMedChem - Wiley Online Library
The pro‐inflammatory cytokine interleukin‐17A (IL‐17) plays an important role in the body's
defense against bacterial and fungal infections. However, overexpression of IL‐17 has been …
defense against bacterial and fungal infections. However, overexpression of IL‐17 has been …
Innovative high throughput medicinal chemistry
M Hadian - 2023 - research.rug.nl
Medicinal Chemistry is the science of the discovery and design of new therapeutic
chemicals and their progress into applicable medicines. Medicinal chemistry may involve …
chemicals and their progress into applicable medicines. Medicinal chemistry may involve …