Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon
binding of complexed IgG, FcγRs can trigger various cellular immune effector functions …

Abstract Purpose of Review Copy number variation (CNV) disorders arise from the dosage
imbalance of one or more gene (s), resulting from deletions, duplications, or other genomic …

Copy number variants (CNVs) are among the largest genetic variants, yet CNVs have not
been effectively ascertained in most genetic association studies. Here we ascertained …

Receptors for the Fc domain of immunoglobulins [Fc receptors (FcRs)] are essential for the
maintenance of antibody-mediated immune responses. FcRs consist of activating-and …

Ulcerative colitis (UC) and rheumatoid arthritis (RA) are immune-mediated inflammatory
diseases (IMIDs) with similar symptoms and common genomics. However, the relationship …

Autoimmune neutropenia (AIN) in early childhood is caused by autoantibodies directed
against antigens on the neutrophil membrane and is a frequent cause of neutropenia in …

Fcγ receptors (FcγR), cell-surface glycoproteins that bind antigen-IgG complexes, control
both humoral and cellular immune responses. The FCGR locus on chromosome 1q23. 3 …

Autoimmune diseases (AIDs) usually share possible common mechanisms, ie, a defect in
the immune tolerance exists due to diverse causes from central and peripheral tolerance …

The importance of structural genetic variants, such as copy number variations (CNVs), in
modulating human disease is being increasingly recognized. Several clinical conditions …

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic
component and etiology characterized by chronic inflammation and autoantibody …