Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
threats one-third of the world's population. Although numerous efforts have been undertaken …

Bacterial fatty acid synthesis is essential for many pathogens and different from the
mammalian counterpart. These features make bacterial fatty acid synthesis a desirable …

In the present investigation, the parent compound 4-amino-5-(4-fluoro-3-phenoxyphenyl)-4
H-1, 2, 4-triazole-3-thiol (1) and its Schiff bases 2, 3, and 4 were subjected to whole-cell anti …

Klebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can
cause life-threatening infections. It has been found as the culprit of many infection outbreaks …

Recent studies have reported the β-ketoacyl-acyl carrier protein KasA as a druggable target
for Mycobacterium tuberculosis. This review summarizes the current status of major classes …

Constantly evolving drug-resistant “superbugs” have caused an urgent demand for novel
antimicrobial agents. Natural products and their analogs have been a prolific source of …

Tuberculosis (TB) has become one of the most significant public health problems in recent
years. Antibiotic therapy remains the mainstay of TB control strategies, but the increasing …

About 70% of the drugs in use are derived from natural products, either used directly or in
chemically modified form. Among all possible small molecules (not greater than 5 kDa), only …

The outer membrane (OM) of Gram-negative bacteria provides an efficient barrier against
external noxious compounds such as antimicrobial agents. Associated with drug target …

Introduction: Two important pathogenic species within the genus Burkholderia, namely
Burkholderia pseudomallei (Bpm) and Burkholderia mallei (Bm), are the causative agents of …