Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry

BG Soliman, AK Nguyen, JJ Gooding… - Advanced …, 2024 - Wiley Online Library
Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical
and mechanical nature of native tissues are needed for advanced models of development …

Compressive stresses in cancer: characterization and implications for tumour progression and treatment

JA Linke, LL Munn, RK Jain - Nature Reviews Cancer, 2024 - nature.com
Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Emerging mRNA technology for liver disease therapy

J Wang, Y Fang, Z Luo, J Wang, Y Zhao - ACS nano, 2024 - ACS Publications
Liver diseases have consistently posed substantial challenges to global health. It is crucial
to find innovative methods to effectively prevent and treat these diseases. In recent times …

The Hippo pathway: organ size control and beyond

P Guo, S Wan, K Guan - Pharmacological Reviews, 2024 - Elsevier
The Hippo signaling pathway is a highly conserved signaling network for controlling organ
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …

Tuning porosity of macroporous hydrogels enables rapid rates of stress relaxation and promotes cell expansion and migration

BA Nerger, K Kashyap, BT Deveney, J Lou… - Proceedings of the …, 2024 - pnas.org
Extracellular matrix (ECM) viscoelasticity broadly regulates cell behavior. While hydrogels
can approximate the viscoelasticity of native ECM, it remains challenging to recapitulate the …

Metabolic dysfunction− associated liver disease and diabetes: Matrix remodeling, fibrosis, and therapeutic implications

W Fan, TM Bradford, NJ Török - … of the New York Academy of …, 2024 - Wiley Online Library
Metabolic dysfunction− associated liver disease (MASLD) and steatohepatitis (MASH) are
becoming the most common causes of chronic liver disease in the United States and …

Modulating Fibrotic Mechanical Microenvironment for Idiopathic Pulmonary Fibrosis Therapy

XN Li, YP Lin, MM Han, YF Fang, L Xing… - Advanced …, 2024 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is exacerbated by injurious mechanical forces that
destabilize the pulmonary mechanical microenvironment homeostasis, leading to alveolar …

Navigating the biophysical landscape: how physical cues steer the journey of bone metastatic tumor cells

P Ouyang, B Cheng, X He, J Lou, X Li, H Guo, F Xu - Trends in Cancer, 2024 - cell.com
Many tumors prefer to metastasize to bone, but the underlying mechanisms remain elusive.
The human skeletal system has unique physical properties, that are distinct from other …

Collagen in hepatocellular carcinoma: A novel biomarker and therapeutic target

D Ding, S Jiang, Y Zu, Y Yang, X Gan… - Hepatology …, 2024 - journals.lww.com
HCC is globally recognized as a major health threat. Despite significant progress in the
development of treatment strategies for liver cancer, recurrence, metastasis, and drug …

Tunable viscoelasticity of alginate hydrogels via serial autoclaving

H Moheimani, S Stealey, S Neal… - Advanced …, 2024 - Wiley Online Library
Alginate hydrogels are widely used as biomaterials for cell culture and tissue engineering
due to their biocompatibility and tunable mechanical properties. Reducing alginate …