Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry
Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical
and mechanical nature of native tissues are needed for advanced models of development …
and mechanical nature of native tissues are needed for advanced models of development …
Compressive stresses in cancer: characterization and implications for tumour progression and treatment
JA Linke, LL Munn, RK Jain - Nature Reviews Cancer, 2024 - nature.com
Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …
abnormal physical microenvironment that fuels cancer progression and confers treatment …
Emerging mRNA technology for liver disease therapy
J Wang, Y Fang, Z Luo, J Wang, Y Zhao - ACS nano, 2024 - ACS Publications
Liver diseases have consistently posed substantial challenges to global health. It is crucial
to find innovative methods to effectively prevent and treat these diseases. In recent times …
to find innovative methods to effectively prevent and treat these diseases. In recent times …
The Hippo pathway: organ size control and beyond
The Hippo signaling pathway is a highly conserved signaling network for controlling organ
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …
Tuning porosity of macroporous hydrogels enables rapid rates of stress relaxation and promotes cell expansion and migration
Extracellular matrix (ECM) viscoelasticity broadly regulates cell behavior. While hydrogels
can approximate the viscoelasticity of native ECM, it remains challenging to recapitulate the …
can approximate the viscoelasticity of native ECM, it remains challenging to recapitulate the …
Metabolic dysfunction− associated liver disease and diabetes: Matrix remodeling, fibrosis, and therapeutic implications
W Fan, TM Bradford, NJ Török - … of the New York Academy of …, 2024 - Wiley Online Library
Metabolic dysfunction− associated liver disease (MASLD) and steatohepatitis (MASH) are
becoming the most common causes of chronic liver disease in the United States and …
becoming the most common causes of chronic liver disease in the United States and …
Modulating Fibrotic Mechanical Microenvironment for Idiopathic Pulmonary Fibrosis Therapy
XN Li, YP Lin, MM Han, YF Fang, L Xing… - Advanced …, 2024 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is exacerbated by injurious mechanical forces that
destabilize the pulmonary mechanical microenvironment homeostasis, leading to alveolar …
destabilize the pulmonary mechanical microenvironment homeostasis, leading to alveolar …
Navigating the biophysical landscape: how physical cues steer the journey of bone metastatic tumor cells
Many tumors prefer to metastasize to bone, but the underlying mechanisms remain elusive.
The human skeletal system has unique physical properties, that are distinct from other …
The human skeletal system has unique physical properties, that are distinct from other …
Collagen in hepatocellular carcinoma: A novel biomarker and therapeutic target
D Ding, S Jiang, Y Zu, Y Yang, X Gan… - Hepatology …, 2024 - journals.lww.com
HCC is globally recognized as a major health threat. Despite significant progress in the
development of treatment strategies for liver cancer, recurrence, metastasis, and drug …
development of treatment strategies for liver cancer, recurrence, metastasis, and drug …
Tunable viscoelasticity of alginate hydrogels via serial autoclaving
Alginate hydrogels are widely used as biomaterials for cell culture and tissue engineering
due to their biocompatibility and tunable mechanical properties. Reducing alginate …
due to their biocompatibility and tunable mechanical properties. Reducing alginate …