Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance
N Gonen, YG Assaraf - Drug Resistance Updates, 2012 - Elsevier
In the past 65 years, antifolates targeting folate metabolism played a pivotal role in drug
treatment of malignant, microbial, parasitic and chronic inflammatory diseases. Drug …
treatment of malignant, microbial, parasitic and chronic inflammatory diseases. Drug …
Mechanisms of membrane transport of folates into cells and across epithelia
R Zhao, N Diop-Bove, M Visentin… - Annual review of …, 2011 - annualreviews.org
Until recently, the transport of folates into cells and across epithelia has been interpreted
primarily within the context of two transporters with high affinity and specificity for folates, the …
primarily within the context of two transporters with high affinity and specificity for folates, the …
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT
was identified in 2006 as the primary transporter for intestinal absorption of dietary folates …
was identified in 2006 as the primary transporter for intestinal absorption of dietary folates …
The intestinal absorption of folates
M Visentin, N Diop-Bove, R Zhao… - Annual review of …, 2014 - annualreviews.org
The properties of intestinal folate absorption were documented decades ago. However, it
was only recently that the proton-coupled folate transporter (PCFT) was identified and its …
was only recently that the proton-coupled folate transporter (PCFT) was identified and its …
Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors
R Zhao, ID Goldman - Molecular aspects of medicine, 2013 - Elsevier
The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and
thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers …
thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers …
Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription
DNA breaks activate the DNA damage response and, if left unrepaired, trigger cellular
senescence. Telomeres are specialized nucleoprotein structures that protect chromosome …
senescence. Telomeres are specialized nucleoprotein structures that protect chromosome …
Heme carrier protein 1 transports heme and is involved in heme-Fe metabolism
S Le Blanc, MD Garrick… - American Journal of …, 2012 - journals.physiology.org
Heme-Fe is an important source of dietary iron in humans; however, the mechanism for
heme-Fe uptake by enterocytes is poorly understood. Heme carrier protein 1 (HCP1) was …
heme-Fe uptake by enterocytes is poorly understood. Heme carrier protein 1 (HCP1) was …
Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance
Background Acute myeloid leukemia (AML) remains a devastating disease with a 5-year
survival rate of less than 30%. AML treatment has undergone significant changes in recent …
survival rate of less than 30%. AML treatment has undergone significant changes in recent …
Role of folate in nonalcoholic fatty liver disease
V Sid, YL Siow, KO - Canadian journal of physiology and …, 2017 - cdnsciencepub.com
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions that are
characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of …
characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of …
The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: hereditary folate malabsorption
R Zhao, S Aluri, ID Goldman - Molecular aspects of medicine, 2017 - Elsevier
The proton-coupled folate transporter (PCFT-SLC46A1) is the mechanism by which folates
are absorbed across the brush-border membrane of the small intestine. The transporter is …
are absorbed across the brush-border membrane of the small intestine. The transporter is …