Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Leukemia is a life-threatening nonepithelial malignant disorder that is characterized by
uncontrolled growth of the hematopoietic cells. To date, there are still unmet needs for …

The members of the Poly (ADP‐ribose) polymerase (PARP) superfamily are involved in
several biological processes and, in particular, in the DNA damage response (DDR). The …

The effective treatment of acute myeloid leukemia (AML) is very challenging. Due to the
immense heterogeneity of this disease, treating it using a “one size fits all” approach is …

One major characteristic of tumor cells is the aberrant activation of epigenetic regulatory
elements, which remodel the tumor transcriptome and ultimately promote cancer …

Cancer genome instability arises from diverse defects in DNA-repair machinery, which make
cancer cells more susceptible to DNA targeting agents. The interrelation between DNA …

Cancer is the most severe disease worldwide. Every year, tens of millions of people are
diagnosed with cancer, and over half of those people will ultimately die from the disease …

Aims The overexpression of ABC transporters on cancer cell membranes is one of the most
common causes of multidrug resistance (MDR). This study investigates the impact of ABCC1 …

The radiotherapy modulators used in clinic have disadvantages of high toxicity and low
selectivity. For the first time, we used the in situ enzyme-instructed self-assembly (EISA) of a …