The role of p53 dysfunction in colorectal cancer and its implication for therapy

M Michel, L Kaps, A Maderer, PR Galle, M Moehler - Cancers, 2021 - mdpi.com
Simple Summary Despite remarkable progress being made by preventive medical check-
ups in the last decades, colorectal cancer (CRC) remains one of the most frequent and …

Dissecting miRNA signature in colorectal cancer progression and metastasis

X Huang, X Zhu, Y Yu, W Zhu, L Jin, X Zhang, S Li… - Cancer letters, 2021 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer
related deaths worldwide. Despite recent advancements in surgical and molecular targeted …

LncRNA XIST/miR-137 axis strengthens chemo-resistance and glycolysis of colorectal cancer cells by hindering transformation from PKM2 to PKM1

H Zheng, M Zhang, X Ke, X Deng, D Li… - Cancer …, 2021 - content.iospress.com
BACKGROUND: Glycolysis was an essential driver of chemo-resistance in colorectal cancer
(CRC), albeit with limited molecular explanations. OBJECTIVE: We strived to elucidate the …

MicroRNAs in cancer therapy: Their involvement in oxaliplatin sensitivity/resistance of cancer cells with a focus on colorectal cancer

M Ashrafizadeh, A Zarrabi, K Hushmandi, F Hashemi… - Life sciences, 2020 - Elsevier
The resistance of cancer cells into chemotherapy has restricted the efficiency of anti-tumor
drugs. Oxaliplatin (OX) being an anti-tumor agent/drug is extensively used in the treatment of …

HOTAIR mediates cisplatin resistance in nasopharyngeal carcinoma by regulating miR-106a-5p/SOX4 axis

W Cao, Y Sun, L Liu, J Yu, J Ji, Y Wang, J Yang - Bioengineered, 2022 - Taylor & Francis
This study explored the function and mechanisms of HOX transcript antisense RNA
(HOTAIR) in the drug resistance of nasopharyngeal carcinoma (NPC). Quantitative PCR …

microRNAs: Small molecules with a large impact on colorectal cancer

S Moazzendizaji, A Sevbitov, F Ezzatifar… - Biotechnology and …, 2022 - Wiley Online Library
Colorectal cancer (CRC) accounts for one of the main cancer‐related mortality and morbidity
worldwide. The molecular mechanisms of CRC development have been broadly …

The Circ_0001367/miR-545-3p/LUZP1 Axis regulates cell proliferation, migration and invasion in glioma cells

X Dong, P Zhang, L Liu, H Li, S Cheng, S Li… - Frontiers in …, 2021 - frontiersin.org
Glioma is the most common primary intracranial malignant tumour in adults. It has a high
incidence and poses a serious threat to human health. Circular RNA is a hotspot of cancer …

Molecular insights into miRNA-driven resistance to 5-fluorouracil and oxaliplatin chemotherapy: miR-23b modulates the epithelial–mesenchymal transition of …

S Gasiulė, N Dreize, A Kaupinis, R Ražanskas… - Journal of clinical …, 2019 - mdpi.com
Although treatment of colorectal cancer with 5-florouracil and oxaliplatin is widely used, it is
frequently followed by a relapse. Therefore, there is an urgent need for profound …

P53‑microRNA interactions regulate the response of colorectal tumor cells to oxaliplatin under normoxic and hypoxic conditions

J Zhang, C Li, L Sun, D Sun… - Oncology Reports, 2023 - spandidos-publications.com
Oxaliplatin (OXA)‑containing regimens are used as first‑line chemotherapy in colorectal
cancer (CRC). However, OXA resistance remains a major challenge in CRC treatment. CRC …

LUZP1 controls cell division, migration and invasion through regulation of the actin cytoskeleton

L Bozal-Basterra, M Gonzalez-Santamarta… - Frontiers in Cell and …, 2021 - frontiersin.org
LUZP1 is a centrosomal and actin cytoskeleton-localizing protein that regulates both
ciliogenesis and actin filament bundling. As the cytoskeleton and cilia are implicated in …