Microglia in cancer therapy-related cognitive impairment

EM Gibson, M Monje - Trends in neurosciences, 2021 - cell.com
Millions of cancer survivors experience a persistent neurological syndrome that includes
deficits in memory, attention, information processing, and mental health. Cancer therapy …

Cancer-related cognitive impairment in patients with non-central nervous system malignancies: an overview for oncology providers from the MASCC Neurological …

SJ Mayo, M Lustberg, HM Dhillon… - Supportive Care in …, 2021 - Springer
Cancer-related cognitive impairment (CRCI) is commonly experienced by individuals with
non-central nervous system cancers throughout the disease and treatment trajectory. CRCI …

Brain-derived neurotrophic factor as a biomarker in cancer-related cognitive impairment among adolescent and young adult cancer patients

DQ Ng, I Cheng, C Wang, CJ Tan, YL Toh, YQ Koh… - Scientific Reports, 2023 - nature.com
Brain-derived neurotrophic factor (BDNF) improves cognitive function by stimulating
neurogenesis and neuroplasticity. We hypothesize that higher plasma BDNF levels are …

Emerging mechanistic underpinnings and therapeutic targets for chemotherapy-related cognitive impairment

EM Gibson, M Monje - Current opinion in oncology, 2019 - journals.lww.com
Traditional cancer therapies induce lasting alterations to multiple neural cell types. Therapy-
induced microglial activation is a critical component of the cause of CRCI, contributing to …

[HTML][HTML] Evidence of brain-derived neurotrophic factor in ameliorating cancer-related cognitive impairment: A systematic review of human studies

DQ Ng, D Chan, P Agrawal, W Zhao, X Xu… - Critical Reviews in …, 2022 - Elsevier
Brain-derived neurotrophic factor (BDNF) plays an essential role in neurogenesis and
neuroplasticity and may be a key protein in cancer-related cognitive impairment (CRCI). This …

Role of exosomes in cancer-related cognitive impairment

YQ Koh, CJ Tan, YL Toh, SK Sze, HK Ho… - International journal of …, 2020 - mdpi.com
A decline in cognitive function following cancer treatment is one of the most commonly
reported post-treatment symptoms among patients with cancer and those in remission, and …

Associations of plasma brain-derived neurotrophic factor (BDNF) and Val66Met polymorphism (rs6265) with long-term cancer-related cognitive impairment in …

NY Yap, NYT Tan, CJ Tan, KWJ Loh, RCH Ng… - Breast Cancer Research …, 2020 - Springer
Purpose Brain-derived neurotrophic factor (BDNF) and the BDNF Val66Met polymorphism
(rs6265) have been implicated in neurodegenerative conditions. This study aimed to …

Self‐reported cognitive outcomes among adolescent and young adult patients with noncentral nervous system cancers

CJ Tan, JJJ Mah, WL Goh, E Poon… - Psycho …, 2020 - Wiley Online Library
Objective Cancer‐related cognitive impairment (CRCI) among adolescent and young adult
(AYA) cancer patients with noncentral nervous system (CNS) cancers has not been well …

[HTML][HTML] The biological intersection between chemotherapy-related cognitive impairment and Alzheimer's disease

M Torre, CA Zanella, MB Feany - The American Journal of Pathology, 2025 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia and one of the leading
causes of death in elderly patients. The number of patients with AD in the United States is …

[HTML][HTML] Perioperative considerations in patients with chemotherapy-induced cognitive impairment: a narrative review

E Guran, J Hu, JS Wefel, C Chung, JP Cata - British journal of anaesthesia, 2022 - Elsevier
Patients with cancer may suffer from a decline in their cognitive function after various cancer
therapies, including surgery, radiation, and chemotherapy, and in some cases, this decline …