The past twenty years have seen great strides in our understanding of the molecular
regulation of differentiation for a whole host of specific cell types. The development of …

The metalloproteinases degrade extracellular matrix (ECM) components and activate growth
factors, thereby contributing to physiological events (tissue remodeling in pregnancy, wound …

Genes encoding subunits of SWI/SNF (BAF) chromatin remodelling complexes are
collectively altered in over 20% of human malignancies, but the mechanisms by which these …

Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant
phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin …

The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the
albumin gene enhancer in liver precursor cells in embryos. To understand how they access …

Starting with multipotent progenitors, hematopoietic lineages are specified by lineage-
restricted transcription factors. The transcription factors that determine the decision between …

Adipocyte differentiation is controlled by a tightly regulated transcriptional cascade in which
PPARγ and members of the C/EBP family are key players. Here we review the roles of …

We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …

An enormous body of work generated over the past three decades has revealed that
eukaryotic gene transcription is a remarkably intricate biochemical process that is tightly …

▪ Abstract It has been a long-standing challenge to decipher the principles that enable cells
to both organize their genomes into compact chromatin and ensure that the genetic …