Prolonged survival of NUT midline carcinoma and current approaches to treatment

HG Kaplan, S Subramaniam, E Vallières… - The oncologist, 2023 - academic.oup.com
NUT midline carcinoma is a rare malignancy most commonly seen in adolescents and
young adults. The disease presents most often in the lung or head and neck area but can be …

Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

A Fichtner, A Marx, P Ströbel, F Bremmer - Histopathology, 2024 - Wiley Online Library
This article will review current aspects of the histopathological, immunohistochemical and
molecular analysis of primary mediastinal germ cell tumours (PMGCTs) as well as their …

Clinicopathological and molecular characterization of a case classified by DNA‑methylation profiling as “CNS embryonal tumor with BRD4–LEUTX fusion”

L Lebrun, S Allard-Demoustiez, N Gilis… - Acta Neuropathologica …, 2023 - Springer
Abstract Central Nervous System (CNS) embryonal tumors represent a heterogeneous
group of highly aggressive tumors occurring preferentially in children but also described in …

[HTML][HTML] Nuclear protein in testis carcinoma of the lung

J Chen, M Li, H Lu - Translational Oncology, 2023 - Elsevier
Nuclear protein in testis (NUT) carcinoma is a kind of highly aggressive and fatal solid tumor
characterized by a rearrangement of the NUT carcinoma family member 1 (NUTM1) gene …

Top 10 histological mimics of neuroendocrine carcinoma you should not miss in the head and neck

CC Juhlin, M Bal - Head and Neck Pathology, 2023 - Springer
Background The spectrum of neuroendocrine neoplasia (NEN) of the head and neck region
is wide-ranging and diverse, including a variety of diagnoses stretching from benign and low …

Differentiated papillary NUT carcinoma: an unexpected, deceptively bland presentation of a sinonasal carcinoma

M Wartenberg, SL Hool, A Marrazzini, R Giger… - Head and neck …, 2023 - Springer
Background In recent years, the list of tumor entities in the sinonasal tract has significantly
expanded, requiring advanced diagnostic testing. We report the case of a 32-year-old …

Deciphering the interplay of histone post-translational modifications in cancer: Co-targeting histone modulators for precision therapy

RR Kawaf, WS Ramadan, R El-Awady - Life Sciences, 2024 - Elsevier
Chromatin undergoes dynamic regulation through reversible histone post-translational
modifications (PTMs), orchestrated by “writers,”“erasers,” and “readers” enzymes …

Imaging of pediatric cervical lymphadenopathy

JA Vaughn - Neuroimaging Clinics of North America, 2023 - Elsevier
Pediatric cervical adenopathy is common occurring in up to 90% of children between the
ages of 4 and 8 year old. 1 The most common cause is reactivity to a variety of viral agents …

Sustained clinical response to Immunotherapy followed by BET inhibitor in a patient with Unresectable Sinonasal NUT carcinoma

H Herbison, S Davis, D Nickless… - Journal of …, 2024 - meridian.allenpress.com
ABSTRACT NUT carcinomas (NCs) are a group of rare tumors that can occur anywhere in
the body and are defined by the fusion of the nuclear protein in testis (NUTM1) resulting in …

The expanding universe of NUTM1 fusions in pediatric cancer

R Charlab, R Racz - Clinical and Translational Science, 2023 - Wiley Online Library
NUT midline carcinoma family member 1 (NUTM1) fusions were originally identified in
poorly differentiated and clinically aggressive carcinomas typically located in the midline …