Penicillin-binding proteins and β-lactam resistance

A Zapun, C Contreras-Martel… - FEMS microbiology …, 2008 - academic.oup.com
A number of ways and means have evolved to provide resistance to eubacteria challenged
by β-lactams. This review is focused on pathogens that resist by expressing low-affinity …

The role of natural environments in the evolution of resistance traits in pathogenic bacteria

JL Martinez - Proceedings of the Royal Society B …, 2009 - royalsocietypublishing.org
Antibiotics are among the most valuable compounds used for fighting human diseases.
Unfortunately, pathogenic bacteria have evolved towards resistance. One important and …

Evolution and spread of antibiotic resistance

BH Normark, S Normark - Journal of internal medicine, 2002 - Wiley Online Library
Antibiotic resistance is a clinical and socioeconomical problem that is here to stay.
Resistance can be natural or acquired. Some bacterial species, such as Pseudomonas …

A global view of antibiotic resistance

JL Martinez, A Fajardo, L Garmendia… - FEMS microbiology …, 2008 - academic.oup.com
Antibiotic resistance is one of the few examples of evolution that can be addressed
experimentally. The present review analyses this resistance, focusing on the networks that …

Triclosan and antimicrobial resistance in bacteria: an overview

SP Yazdankhah, AA Scheie, EA Høiby… - Microbial drug …, 2006 - liebertpub.com
Triclosan is a widely used biocide that is considered as an effective antimicrobial agent
against different microorganisms. It is included in many contemporary consumer and …

Diversity of PspA: Mosaic Genes and Evidence for Past Recombination in Streptococcus pneumoniae

SK Hollingshead, R Becker, DE Briles - Infection and immunity, 2000 - Am Soc Microbiol
Pneumococcal surface protein A (PspA) is a serologically variable protein of Streptococcus
pneumoniae. Twenty-four diverse alleles of the pspA gene were sequenced to investigate …

Antibiotic resistance in general dental practice—a cause for concern?

LC Sweeney, J Dave, PA Chambers… - Journal of …, 2004 - academic.oup.com
This review examines the contribution dental prescribing makes to the selection of antibiotic
resistance in bacteria of the oral flora. The antibiotics commonly used in dental prescribing …

Antibiotic therapy of community respiratory tract infections: strategies for optimal outcomes and minimized resistance emergence

P Ball, F Baquero, O Cars, T File, J Garau… - Journal of …, 2002 - academic.oup.com
Widespread, increasing antibiotic resistance amongst the major respiratory pathogens has
compromised traditional therapy of the major infective respiratory syndromes, including …

Molecular Mechanisms of β-Lactam Resistance in Streptococcus Pneumoniae

R Hakenbeck, R Brückner, D Denapaite… - Future …, 2012 - Taylor & Francis
Alterations in the target enzymes for β-lactam antibiotics, the penicillin-binding proteins
(PBPs), have been recognized as a major resistance mechanism in Streptococcus …

Resistance among Streptococcus pneumoniae: Implications for Drug Selection

PC Appelbaum - Clinical infectious diseases, 2002 - academic.oup.com
Streptococcus pneumoniae is an important pathogen in many community-acquired
respiratory infections in the United States and a leading cause of morbidity and mortality …