Metformin role in Parkinson's disease: a double-sword effect

M Alrouji, HM Al-Kuraishy, AI Al-Gareeb… - Molecular and Cellular …, 2024 - Springer
Parkinson's disease (PD) is a common neurodegenerative disease developed due to the
degeneration of dopaminergic neurons in the substantia nigra. There is no single effective …

Actions of metformin in the brain: a new perspective of metformin treatments in related neurological disorders

N Li, T Zhou, E Fei - International Journal of Molecular Sciences, 2022 - mdpi.com
Metformin is a first-line drug for treating type 2 diabetes mellitus (T2DM) and one of the most
commonly prescribed drugs in the world. Besides its hypoglycemic effects, metformin also …

Emerging neuroprotective effect of metformin in Parkinson's disease: A molecular crosstalk

YN Paudel, E Angelopoulou, C Piperi, MF Shaikh… - Pharmacological …, 2020 - Elsevier
Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by the
progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and …

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

E Barini, O Antico, Y Zhao, F Asta, V Tucci… - Molecular …, 2016 - Springer
Background Alzheimer disease (AD) and other tauopathies develop cerebral intracellular
inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence …

Association between metformin and neurodegenerative diseases of observational studies: systematic review and meta-analysis

F Ping, N Jiang, Y Li - BMJ Open Diabetes Research and Care, 2020 - drc.bmj.com
Background and aims Aging becomes a growing global concern with an increased risk of
neurodegenerative diseases (NDs) that mainly consist of cognitive decline and Parkinson …

Haloperidol‐induced catalepsy as an animal model for parkinsonism: A systematic review of experimental studies

I Waku, MS Magalhaes, CO Alves… - European Journal of …, 2021 - Wiley Online Library
Several useful animal models for parkinsonism have been developed so far. Haloperidol‐
induced catalepsy is often used as a rodent model for the study of motor impairments …

Intranasal cerium oxide nanoparticles improves locomotor activity and reduces oxidative stress and neuroinflammation in haloperidol-induced parkinsonism in rats

Mohammad, UA Khan, MH Warsi… - Frontiers in …, 2023 - frontiersin.org
Introduction: Cerium oxide nanoparticles (CONPs) have been investigated for their
therapeutic potential in Parkinson's disease (PD) due to their potent and regenerative …

Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats

N Shivavedi, M Kumar, GNVC Tej, PK Nayak - Brain Research, 2017 - Elsevier
Diabetes mellitus and depression are the common comorbid disorders affecting humans
worldwide. There is an unmet need to develop therapeutic strategies to treat both diabetes …

Metformin prevents nigrostriatal dopamine degeneration independent of AMPK activation in dopamine neurons

JA Bayliss, MB Lemus, VV Santos, M Deo, JS Davies… - PloS one, 2016 - journals.plos.org
Metformin is a widely prescribed drug used to treat type-2 diabetes, although recent studies
show it has wide ranging effects to treat other diseases. Animal and retrospective human …

Therapies modulating insulin resistance in Parkinson's disease: a cross talk

T Sharma, D Kaur, AK Grewal, TG Singh - Neuroscience Letters, 2021 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder linked with aging and primarily
involves dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc). The …