Sexual dimorphism in cancer

A Clocchiatti, E Cora, Y Zhang, GP Dotto - Nature Reviews Cancer, 2016 - nature.com
The incidence of many types of cancer arising in organs with non-reproductive functions is
significantly higher in male populations than in female populations, with associated …

Sexual dimorphism in solid and hematological malignancies

I Ben-Batalla, ME Vargas-Delgado, L Meier… - Seminars in …, 2019 - Springer
Cancer represents a leading cause of death with continuously increasing incidence
worldwide. Many solid cancer types in non-reproductive organs are significantly more …

Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice

HJ Hartwell, KY Petrosky, JG Fox… - Proceedings of the …, 2014 - National Acad Sciences
Women are more resistant to hepatocellular carcinoma (HCC) than men despite equal
exposure to major risk factors, such as hepatitis B or C virus infection. Female resistance is …

Estrogen receptor-α suppresses liver carcinogenesis and establishes sex-specific gene expression

MH O'Brien, HC Pitot, SH Chung, PF Lambert… - Cancers, 2021 - mdpi.com
Simple Summary The hormone estrogen is well known for its role in promoting breast and
ovarian cancer. Estrogen has the opposite effect on the liver, which it protects from cancer …

Reproductive factors, menopausal hormone therapies and primary liver cancer risk: a systematic review and dose–response meta-analysis of observational studies

GC Zhong, Y Liu, N Chen, FB Hao… - Human …, 2017 - academic.oup.com
BACKGROUND A striking gender disparity in the incidence and outcome of primary liver
cancer (PLC) has been well recognized. Mounting evidence from basic research suggests …

Menopausal hormone therapy use and risk of primary liver cancer in the clinical practice research datalink

KA McGlynn, K Hagberg, J Chen… - … journal of cancer, 2016 - Wiley Online Library
Primary liver cancer occurs less commonly among women than men in almost all countries.
This discrepancy has suggested that hormone levels and/or exogenous hormone use could …

The role for estrogen receptor-alpha and prolactin receptor in sex-dependent DEN-induced liver tumorigenesis

RM Bigsby, A Caperell-Grant - Carcinogenesis, 2011 - academic.oup.com
Mice treated neonatally with diethylnitrosamine (DEN) develop liver tumors in a male-
dominant manner, reflecting the male bias in human hepatocellular carcinoma. Evidence …

Menstrual factors, reproductive history and liver cancer risk: findings from a prospective cohort study in Chinese women

JY Tuo, HL Li, J Wang, J Fang, YT Tan… - … , Biomarkers & Prevention, 2022 - AACR
Background: Many studies suggested that menstrual and reproductive factors affected the
gender disparity in liver carcinogenesis, but the results were inconsistent. Moreover, there …

[PDF][PDF] 外消旋雌马酚及其对映异构体的肿瘤预防研究进展

窦宇琪, 陈博天, 马德福 - 肿瘤代谢与营养电子杂志 - 182.92.200.144
雌马酚是黄豆苷元的代谢产物, 是大豆异黄酮及其代谢产物中抗氧化活性最强的一种, 有2
种对映异构体. 大豆异黄酮的抗肿瘤效应取决于其代谢产物雌马酚. 但雌马酚及其对映异构体对 …

Domperidone use and risk of primary liver cancer in the Clinical Practice Research Datalink

JE Thistle, JL Petrick, B Yang, MC Bradley… - Cancer …, 2018 - Elsevier
Background Pronounced sex-disparity in liver cancer suggests a role for hormones, one of
which could be prolactin. Stimulation of prolactin production in mice via domperidone has …