The emerging role of Piezo1 in the musculoskeletal system and disease

L Lei, Z Wen, M Cao, H Zhang, SKK Ling… - …, 2024 - pmc.ncbi.nlm.nih.gov
Piezo1, a mechanosensitive ion channel, has emerged as a key player in translating
mechanical stimuli into biological signaling. Its involvement extends beyond physiological …

The role of mechanically sensitive ion channel Piezo1 in bone remodeling

Y Du, B Xu, Q Li, C Peng, K Yang - Frontiers in Bioengineering and …, 2024 - frontiersin.org
Piezo1 (2010) was identified as a mechanically activated cation channel capable of sensing
various physical forces, such as tension, osmotic pressure, and shear force. Piezo1 …

[HTML][HTML] Three-dimensional matrix stiffness modulates mechanosensitive and phenotypic alterations in oral squamous cell carcinoma spheroids

M Sheth, M Sharma, M Lehn, HA Reza, T Takebe… - APL …, 2024 - pubs.aip.org
Extracellular biophysical cues such as matrix stiffness are key stimuli tuning cell fate and
affecting tumor progression in vivo. However, it remains unclear how cancer spheroids in a …

Identification of key genes and pathways associated with sex differences in rheumatoid arthritis based on bioinformatics analysis

T Wang, F Zeng, X Li, Y Wei, D Wang, W Zhang… - Clinical …, 2023 - Springer
Introduction Women are more likely than men to develop the chronic, progressive
autoimmune disease known as rheumatoid arthritis (RA). Although there may be a complex …

Landscape analysis of m6A modification reveals the dysfunction of bone metabolism in osteoporosis mice

L Zheng, C Lan, X Gao, A Zhu, Y Chen, J Lin, S Yan… - Heliyon, 2025 - cell.com
Osteoporosis (OP) is a prevalent chronic bone metabolic disorder that affects the elderly
population, leading to an increased susceptibility to bone fragility. Despite extensive …

[HTML][HTML] Peripheral serum iTRAQ-based proteomic characteristics of carbon tetrachloride-induced acute liver injury in Macaca fascicularis

M Yufa, C Dongmei, L Wei, L Shuangxing, S Li… - Toxicology Reports, 2024 - Elsevier
Carbon tetrachloride (CCl 4) is a potent chemical compound that can induce liver cells
necrosis. The purpose of this study was to evaluate the hepatic toxicity of CCl 4 exposure in …

机械敏感性离子通道蛋白Piezo1 与临床疾病相关性的研究进展.

郝晓蓓, 王庆, 陈俊羽, 翁恒, 杨敏… - Journal of Modern …, 2024 - search.ebscohost.com
Piezo1protein, asanovelmechanosensitiveionchannelclos… stimulationsignals, playsasignificantroleinrespondingtomechan…
. This proteiniswidelydistributedintheorgansandtis…, andhasbeenwidelyconcernedbytheacadem …

Low-intensity transcranial ultrasound (LITUS) exerts neuroprotective effects by modulating inflammatory responses via the Piezo1-Dkk3/Ca 2+/PI3K-Akt signaling …

S Xu, L Gu, Q Liu, B Bao, Q Jin, Y Ma, S Zhou, B Li… - 2024 - researchsquare.com
Background Post-cardiac arrest brain injury (PCABI) contributes to unfavorable outcomes
following cardiopulmonary resuscitation (CPR) significantly, with effective therapeutic …