The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …

Like physics in the 19th century, biology and molecular biology in particular, has been
fertilized and enhanced like few other scientific fields, by the incorporation of mathematical …

ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in
numerous diseases, but study of the structure and function of these proteins is often …

Background Dapagliflozin inhibits the sodium‐glucose–linked transporter 2 in the renal
proximal tubule, thereby promoting glycosuria to reduce hyperglycemia in type 2 diabetes …

Reabsorption of filtered solutes from the glomerular filtrate and excretion of waste products
and xenobiotics are the main functions of the renal proximal tubular (PT) epithelium. A …

During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes
due to inadequate renal clearance. Here, the interaction between uremic toxins and two …

Multidrug-resistant protein 4 (MRP4), a member of the C subfamily of ATP-binding cassette
transporters, is distributed in a variety of tissues and a number of cancers. As a drug …

Multidrug resistance-associated protein 4 (MRP4) is an ATP-binding cassette (ABC)
transporter expressed at multiple tissue barriers where it actively extrudes a wide variety of …

Abstract Multidrug resistance protein 4 (MRP4) is a broadly expressed ATP-binding cassette
transporter that is unique among the MRP subfamily for transporting prostanoids, a group of …

Abstract Multidrug resistance protein 4 (MRP4/ABCC4), a member of the ATP-binding
cassette (ABC) transporter superfamily, is an organic anion transporter capable of effluxing a …