Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Management of appendix neuroendocrine neoplasms: insights on the current guidelines

A Mohamed, S Wu, M Hamid, A Mahipal, S Cjakrabarti… - Cancers, 2022 - mdpi.com
Appendiceal neuroendocrine neoplasms (ANENs) usually present as incidental findings at
the time of appendectomy for acute appendicitis. They are rare, accounting for only 0.5–1 …

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours

A Rinke, V Ambrosini, C Dromain… - Journal of …, 2023 - Wiley Online Library
This ENETS guidance paper, developed by a multidisciplinary working group, provides an
update on the previous colorectal guidance paper in a different format. Guided by key …

Phase 3 trial of cabozantinib to treat advanced neuroendocrine tumors

JA Chan, S Geyer, T Zemla, MV Knopp… - … England Journal of …, 2024 - Mass Medical Soc
Background Treatment options for patients with advanced neuroendocrine tumors are
limited. The efficacy of cabozantinib in the treatment of previously treated, progressive …

European neuroendocrine tumor society (ENETS) 2024 guidance paper for the management of well‐differentiated small intestine neuroendocrine tumours

A Lamarca, DK Bartsch, M Caplin… - Journal of …, 2024 - Wiley Online Library
Both the incidence and prevalence of well‐differentiated neuroendocrine tumours from the
small intestine (Si‐NET) are gradually increasing. Most patients have non‐functioning …

Neuroendocrine tumors: a relevant clinical update

EN Rizen, AT Phan - Current Oncology Reports, 2022 - Springer
Abstract Purpose of Review The field of neuroendocrine oncology has changed much since
the time of Oberndorfer first described and coined the term carcinoid. The purpose of this …

Everolimus with or without bevacizumab in advanced pNET: CALGB 80701 (Alliance)

MH Kulke, FS Ou, D Niedzwiecki… - Endocrine-related …, 2022 - erc.bioscientifica.com
Treatment with the mTOR inhibitor everolimus improves progression-free survival in
pancreatic neuroendocrine tumors, but it is not known if the addition of a VEGF pathway …

Tyrosine kinase inhibitors and immunotherapy updates in neuroendocrine neoplasms

O Mosalem, MB Sonbol, TR Halfdanarson… - Best Practice & Research …, 2023 - Elsevier
Neuroendocrine tumors (NETs) represent a heterogeneous group of malignancies that arise
from neuroendocrine cells dispersed throughout the organs/tissues of the body. Treatment of …

Multimodal management of grade 1 and 2 pancreatic neuroendocrine tumors

U Marchese, M Gaillard, A Pellat, S Tzedakis… - Cancers, 2022 - mdpi.com
Simple Summary As we are facing an increasing incidence of pancreatic neuroendocrine
tumors (pNETs), it appears necessary to better classify this disease—and in 2017 the WHO …

Therapy resistant gastroenteropancreatic neuroendocrine tumors

K McClellan, EY Chen, A Kardosh, CD Lopez… - Cancers, 2022 - mdpi.com
Simple Summary The medical care for patients with neuroendocrine tumors arising from the
intestines, pancreas, or stomach is frequently limited by the development resistance to …