The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

ABSTRACT C-Myc overexpression is a common finding in pancreatic cancer and predicts
the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby …

Pancreatic ductal adenocarcinoma (PDAC) is responsible for 7.3% of all cancer deaths.
Even though there is a steady increase in patient survival for most cancers over the …

Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …

Dysregulation of the cell cycle machinery leads to genomic instability and is a hallmark of
cancer associated with chemoresistance and poor prognosis in colorectal cancer (CRC) …

It is well established that mutations in the canonical WNT-signalling pathway play a major
role in various cancers. Critical to developing new therapeutic strategies is understanding …

Colorectal cancers (CRCs) are composed of an amalgam of cells with distinct genotypes
and phenotypes. Here, we reveal a previously unappreciated heterogeneity in the …

Human development relies on the correct replication, maintenance and segregation of our
genetic blueprints. How these processes are monitored across embryonic lineages, and why …

Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …