Highlights•Formulation design comprises complicated stages.•Formulation optimization
requires an exhaustive experimental work.•Computational tools help in formulation …

Understanding interparticle interactions in powder systems is crucial to pharmaceutical
powder processing. Nevertheless, there remains a great challenge in identifying the key …

As a consequence of increasing computer power and more readily useable commercial and
open source codes, Discrete Element Method (DEM) is becoming widely used across a …

Material properties are known to have a significant impact on pharmaceutical manufacturing
performance, particularly for solid product processes. Evaluating the performance of a …

The objective of this work is to present a review of computational tools and models for
pharmaceutical processes, specifically those for the continuous manufacture of solid dosage …

This paper studies systematically the effect of a feed frames, a device used in rotary tablet
presses to drive the powders into compression dies, on the properties of the powders …

Tablet compression has great significance in the pharmaceutical industry since most of the
drugs are in the tablet dosage form. The tablet press feed frame is used to fill powder into the …

With the emergence of quality by design in the pharmaceutical industry, it becomes
imperative to gain a deeper mechanistic understanding of factors impacting the flow of a …

This paper presents an experimental and numerical study of the packing, compression, and
caking behaviour of spray dried detergent (SDD) powders with a two-fold aim: an …

Based on characterization of a wide range of fillers and APIs, thirty divergent blends were
composed and subsequently compressed on a rotary tablet press, varying paddle speed …