Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …
to acute respiratory distress syndrome and death. Three highly pathogenic human …
Cytokine storm in COVID-19: the current evidence and treatment strategies
Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes
coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has …
coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has …
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
JD Domizio, MF Gulen, F Saidoune, VV Thacker… - Nature, 2022 - nature.com
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung
pathology and extrapulmonary complications,. Type I interferons (IFNs) have an essential …
pathology and extrapulmonary complications,. Type I interferons (IFNs) have an essential …
[HTML][HTML] Longitudinal analyses reveal immunological misfiring in severe COVID-19
Recent studies have provided insights into the pathogenesis of coronavirus disease 2019
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …
[PDF][PDF] Type I and type III interferons–induction, signaling, evasion, and application to combat COVID-19
A Park, A Iwasaki - Cell host & microbe, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …
[PDF][PDF] Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19
SA Lowery, A Sariol, S Perlman - Cell host & microbe, 2021 - cell.com
COVID-19 can result in severe disease characterized by significant immunopathology that is
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
A single-cell atlas of the peripheral immune response in patients with severe COVID-19
There is an urgent need to better understand the pathophysiology of Coronavirus disease
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …
[PDF][PDF] Heightened innate immune responses in the respiratory tract of COVID-19 patients
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …
infection have posed a severe threat to global public health. It is unclear how the human …
Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
BT Bradley, H Maioli, R Johnston, I Chaudhry, SL Fink… - The Lancet, 2020 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of
an ongoing pandemic, with increasing deaths worldwide. To date, documentation of the …
an ongoing pandemic, with increasing deaths worldwide. To date, documentation of the …
SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes
J Nikolich-Zugich, KS Knox, CT Rios, B Natt… - Geroscience, 2020 - Springer
Abstract SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …