Roles and regulation of tRNA-derived small RNAs in animals

S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …

Amyotrophic lateral sclerosis

O Hardiman, A Al-Chalabi, A Chio, EM Corr… - Nature reviews Disease …, 2017 - nature.com
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

Stress granules, P-bodies and cancer

P Anderson, N Kedersha, P Ivanov - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize
post-transcriptional control mechanisms to re-program gene expression in ways that …

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

S Honda, P Loher, M Shigematsu… - Proceedings of the …, 2015 - National Acad Sciences
Sex hormones and their receptors play critical roles in the development and progression of
the breast and prostate cancers. Here we report that a novel type of transfer RNA (tRNA) …

[HTML][HTML] tRNA fragments in human health and disease

P Anderson, P Ivanov - FEBS letters, 2014 - Elsevier
Transfer RNA (tRNA) is traditionally considered to be an adaptor molecule that helps
ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have …

Three decades of research on angiogenin: a review and perspective

J Sheng, Z Xu - Acta Biochim Biophys Sin, 2016 - academic.oup.com
As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first
isolated and identified solely by its ability to induce new blood vessel formation, and now, it …

Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3–mediated gene silencing

Z Su, C Kuscu, A Malik, E Shibata, A Dutta - Journal of Biological Chemistry, 2019 - ASBMB
tRNA fragments (tRFs) and tRNA halves have been implicated in various cellular processes,
including gene silencing, translation, stress granule assembly, cell differentiation …

Immune modulation by human secreted RNases at the extracellular space

L Lu, J Li, M Moussaoui, E Boix - Frontiers in immunology, 2018 - frontiersin.org
The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses
eight functional members in humans. The proteins are secreted by diverse innate immune …

Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

MD Boppart, ZS Mahmassani - American Journal of …, 2019 - journals.physiology.org
The α7β1-integrin is a transmembrane adhesion protein that connects laminin in the
extracellular matrix (ECM) with actin in skeletal muscle fibers. The α7β1-integrin is highly …

Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells

KA Goncalves, L Silberstein, S Li, N Severe, MG Hu… - Cell, 2016 - cell.com
Regulation of stem and progenitor cell populations is critical in the development,
maintenance, and regeneration of tissues. Here, we define a novel mechanism by which a …