Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle …
P Anderson, N Kedersha, P Ivanov - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that …
S Honda, P Loher, M Shigematsu… - Proceedings of the …, 2015 - National Acad Sciences
Sex hormones and their receptors play critical roles in the development and progression of the breast and prostate cancers. Here we report that a novel type of transfer RNA (tRNA) …
Transfer RNA (tRNA) is traditionally considered to be an adaptor molecule that helps ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have …
J Sheng, Z Xu - Acta Biochim Biophys Sin, 2016 - academic.oup.com
As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first isolated and identified solely by its ability to induce new blood vessel formation, and now, it …
tRNA fragments (tRFs) and tRNA halves have been implicated in various cellular processes, including gene silencing, translation, stress granule assembly, cell differentiation …
L Lu, J Li, M Moussaoui, E Boix - Frontiers in immunology, 2018 - frontiersin.org
The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses eight functional members in humans. The proteins are secreted by diverse innate immune …
The α7β1-integrin is a transmembrane adhesion protein that connects laminin in the extracellular matrix (ECM) with actin in skeletal muscle fibers. The α7β1-integrin is highly …
KA Goncalves, L Silberstein, S Li, N Severe, MG Hu… - Cell, 2016 - cell.com
Regulation of stem and progenitor cell populations is critical in the development, maintenance, and regeneration of tissues. Here, we define a novel mechanism by which a …