The large conductance calcium-and voltage-activated K+ channel (KCa1. 1, BK, MaxiK) is
ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular …

Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology,
both in neuronal and non-neuronal cells and tissues. Through negative feedback between …

Contraction and relaxation of the detrusor smooth muscle (DSM), which makes up the wall of
the urinary bladder, facilitates the storage and voiding of urine. Several families of K+ …

Abstract The large-conductance, Ca 2+-and voltage-activated K+(BK) channel is
ubiquitously expressed in mammalian tissues and displays diverse biophysical or …

The physiological functions of the urinary bladder are to store and periodically expel urine.
These tasks are facilitated by the contraction and relaxation of the urinary bladder smooth …

The large-conductance voltage-and Ca2+-activated K+ (BK) channel is expressed in many
smooth muscle types, but its role in human detrusor smooth muscle (DSM) is unclear. With a …

Urinary bladder smooth muscle (UBSM), also known as detrusor smooth muscle, forms the
bladder wall and ultimately determines the two main attributes of the organ: urine storage …

Coded by a single gene (Slo1, KCM) and activated by depolarizing potentials and by a rise
in intracellular Ca2+ concentration, the large conductance voltage-and Ca2+-activated K+ …

The heart generates and propagates action potentials through synchronized activation of ion
channels allowing inward Na+ and Ca2+ and outward K+ currents. There are a number of …

Overactive bladder syndrome is frequently associated with increased detrusor smooth
muscle (DSM) contractility. We tested the hypothesis that pharmacological activation of the …