Background Circadian rhythm is characterised by daily variations in biological activity to
align with the light and dark cycle. These diurnal variations, in turn, influence physiological …

Fibrosis, characterized by excessive extracellular matrix accumulation, disrupts normal
tissue architecture, causes organ dysfunction, and contributes to numerous chronic …

Background The prevalence of ferroptosis in diabetic kidney tubules has been documented,
yet the underlying mechanism remains elusive. The aim of this study was to ascertain the …

Cardiovascular function and adipose metabolism were markedly influenced under high
altitudes. However, the interplay between adipokines and heart under hypoxia remains to be …

Patients with active ulcerative colitis (UC) display a misalignment of the circadian clock,
which plays a vital role in various immune functions. Our aim was to characterize the …

Nuclear receptors (NRs) are ligand-dependent transcription factors required for liver
development and function. As a consequence, NRs have emerged as attractive drug targets …

REV-ERB receptors are members of the nuclear receptor superfamily of proteins, which act
as both intracellular receptors and transcription factors, therefore modulating the expression …

Background The disorder of circadian rhythm could be a key factor mediating fibrotic lung
disease Therefore, our study aims to determine the diagnostic value of circadian rhythm …

The circadian clock is involved in the pathogenesis of nonalcoholic steatohepatitis (NASH),
and the target pathways of many NASH candidate drugs are controlled by the circadian …

Аннотация ОБОСНОВАНИЕ. Риск развития микро-и макрососудистых заболеваний у
пациентов с сахарным диабетом 2 типа (СД2) увеличивается на фоне …