Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

SUMMARY DNA repair and DNA damage tolerance machineries are crucial to overcome
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …

In their seminal publication describing the structure of the DNA double helix 1, Watson and
Crick wrote what may be one of the greatest understatements in the scientific literature …

Recent studies have described a DNA damage tolerance pathway choice that involves a
competition between PrimPol-mediated repriming and fork reversal. Screening different …

Translesion synthesis (TLS) is a DNA damage tolerance mechanism that allows continued
DNA synthesis, even in the presence of damaged DNA templates. Mammals have multiple …

Eukaryotic genomes are replicated with high fidelity to assure the faithful transmission of
genetic information from one generation to the next. The accuracy of replication relies …

The great Chinese strategist Sun Tsu wrote,“So it is said that if you know your enemies and
know yourself, you will fight without danger in battles.” 1 This quote was originally meant to …

Although p21 upregulation is required to block cell-cycle progression following many types
of genotoxic insult, UV irradiation triggers p21 proteolysis. The significance of the increased …

Living organisms not only repair DNA damage induced by environmental agents and
endogenous cellular metabolites, but have also developed mechanisms to survive in the …

It has been two decades since the discovery of the most mutagenic human DNA
polymerase, polymerase iota (Polι). Since then, the biochemical activity of this translesion …