Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based
on analytical chemistry principles and technological tools, particularly mass spectrometry …

Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

Progress toward the development of efficacious therapies for Alzheimer's disease (AD) is
halted by a lack of understanding early underlying pathological mechanisms. Systems …

Abstract Changes to lipid metabolism are tightly associated with the onset and pathology of
Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and …

Lipidomics research could provide insights of pathobiological mechanisms in Alzheimer's
disease. This study explores a battery of plasma lipids that can differentiate Alzheimer's …

Lipids are vital biological molecules and play multiple roles in cellular function of
mammalian organisms such as cellular membrane anchoring, signal transduction, material …

Introduction The aim of this study was to (1) replicate previous associations between six
blood lipids and Alzheimer's disease (AD)(Proitsi et al 2015) and (2) identify novel …

Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease.
Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that …