Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …

More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

BACKGROUND Androgens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are
essential in human ovarian folliculogenesis. However, the interactions between these four …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

BACKGROUND Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory
infertility and menstrual cycle abnormalities, but the factors responsible for failure to select a …

BACKGROUND The primary determinant of reproductive age in women is the number of
ovarian non-growing (primordial, intermediate and primary) follicles (NGFs). To better …

Recent studies challenge the previous view that apoptosis within the granulosa cells of the
maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of …

Androgens in women, as well as in men, are intrinsic to maintenance of (i) reproductive
competency,(ii) cardiac health,(iii) appropriate bone remodeling and mass retention,(iii) …

OBJECTIVE: To determine that anti-Müllerian hormone (AMH) has been shown to inhibits
E2 production in rodents and in luteinized granulosa cells (GC). We determined whether this …

BACKGROUND Serum concentrations of anti-Müllerian hormone (AMH) correlate with
oocyte yield in assisted reproduction treatment (ART) cycles, however, performance of AMH …