Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Aberrant epigenetic modifications are emerging as potent drivers of tumor initiation and
progression. The deregulation of H3K27me3 marks has shown to play an important role in …

The initiation of prostate cancer has been long associated with DNA copy-number
alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations …

Changes in modern lifestyle provoke a series of metabolic stresses such as hyperlipidemia.
Excessive free fatty acids induce cardiomyocyte metabolic reprogramming and …

Epigenetic aberration is one of the major driving factors in human cancer, often leading to
acquired resistance to chemotherapies. Various small molecule epigenetic modulators have …

Androgen and androgen deprivation (castration) therapies, including androgen receptor
antagonists, are clinically used to treat patients with prostate cancer. However, most …

Purpose: The purpose of this study was to investigate the antitumor effects of GSK-J4 on
retinoblastoma, as well as its related biological functions and molecular mechanisms …

Introduction: Epigenetic-targeted therapy has been increasingly applied in the treatment of
cancers. Lysine (K)-specific demethylase 6B (KDM6B) is an epigenetic enzyme involved in …

Prostate cancer is one of the most common malignancies among men worldwide. Besides
genetic alterations, epigenetic modulations including DNA methylation, histone …

Le cancer de la prostate est le deuxième cancer le plus fréquent chez l'homme dans le
monde. Les changements épigénétiques en réponse à des événements externes …